Medical Therapy for Ocular Allergy

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Presentation transcript:

Medical Therapy for Ocular Allergy STEFAN D. TROCME, M.D. Mayo Clinic Proceedings Volume 67, Issue 6, Pages 557-565 (June 1992) DOI: 10.1016/S0025-6196(12)60464-9 Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Vernal keratoconjunctivitis with cobblestone appearance of numerous large, inflammatory papillae on undersurface of upper eyelid. Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Horner's points or Trantas' dots. These inflammatory nodules are composed of eosinophils and are found near corneoscleral limbus in vernal keratoconjunctivitis; they are virtually pathognomonic for the disorder. Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 A shield ulcer of the cornea in a patient with vernal keratoconjunctivitis. Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 4 Photomicrographs demonstrating deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis. A, Section of conjunctiva. Note papilla formation and subepithelial inflammatory infiltrate. (Hematoxylin-eosin; original magnification, ×160.) B, Serial section stained for immunofluorescence, showing extensive staining for major basic protein. (Original magnification, ×160.) (From Trocme and associates.32 Published with permission from The American Journal of Ophthalmology. Coypright by the Ophthalmic Publishing Company.) Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 5 Severe blepharitis and perioral lesions with probable bacterial superinfection in a patient with atopic keratoconjunctivitis. Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 6 An anterior lenticular opacity (cataract) associated with atopic keratoconjunctivitis. Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 7 Giant papillary conjunctivitis, an allergic response associated primarily with wearing of contact lenses. Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 8 Photomicrographs of deposition of eosinophil granule major basic protein in giant papillary conjunctivitis. A, Section of conjunctiva. Note accumulation of inflammatory cells in substantia propria. (Hematoxylin-eosin; original magnification, ×160.) B, Serial section stained for immunofluorescence, showing focal staining for major basic protein. (Original magnification, ×160.) (From Trocme and associates.32 Published with permission from The American Journal of Ophthalmology. Copyright by the Ophthalmic Publishing Company.) Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 9 Contact lens from patient with atopy. A, Staining with hematoxylin-eosin shows some surface deposits. B, Staining for immunofluorescence shows prominent eosinophil granule major basic protein, primarily on anterior surface. (From Trocme and associates.44 By permission of Contact Lens Association of Ophthalmologists.) Mayo Clinic Proceedings 1992 67, 557-565DOI: (10.1016/S0025-6196(12)60464-9) Copyright © 1992 Mayo Foundation for Medical Education and Research Terms and Conditions