Volume 139, Issue 5, Pages e1 (November 2010)

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Volume 139, Issue 5, Pages 1549-1558.e1 (November 2010) Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis Archana S. Rao, Banny S. Wong, Michael Camilleri, Suwebatu T. Odunsi–Shiyanbade, Sanna McKinzie, Michael Ryks, Duane Burton, Paula Carlson, Jesse Lamsam, Ravinder Singh, Alan R. Zinsmeister Gastroenterology Volume 139, Issue 5, Pages 1549-1558.e1 (November 2010) DOI: 10.1053/j.gastro.2010.07.052 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Illustration of bile acid enterohepatic circulation and homeostasis and relevant proteins with genetic variation tested in this study. Gastroenterology 2010 139, 1549-1558.e1DOI: (10.1053/j.gastro.2010.07.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Study flow chart and patient demographics. Gastroenterology 2010 139, 1549-1558.e1DOI: (10.1053/j.gastro.2010.07.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Effects of placebo or CDC on overall colonic transit and time for AC emptying. *Overall significant difference among placebo and CDC groups (ANCOVA P = .005 for GC 24 and P = .028 for AC t½). Gastroenterology 2010 139, 1549-1558.e1DOI: (10.1053/j.gastro.2010.07.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 4 Correlation between gastric emptying and colonic transit for each treatment group. Gastroenterology 2010 139, 1549-1558.e1DOI: (10.1053/j.gastro.2010.07.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 5 Effects of treatment on AC colon emptying in relation to genotype. The upper panel shows results by genotype in the entire cohort (health and IBS-C). The lower panel shows results for KLB for the different phenotype subgroups and illustrates the genotype-by-treatment-by-phenotype interaction. Gastroenterology 2010 139, 1549-1558.e1DOI: (10.1053/j.gastro.2010.07.052) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 Effect of CDC versus placebo on bowel function (stool consistency measured by Bristol Stool Form Scale; stool frequency measured as daily number of bowel movements; ease of passage of stool range: 1 = manual disimpaction to 7 = incontinence). Gastroenterology 2010 139, 1549-1558.e1DOI: (10.1053/j.gastro.2010.07.052) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 2 Relationship between baseline serum 7αC4 level and colonic transit in the placebo group. Gastroenterology 2010 139, 1549-1558.e1DOI: (10.1053/j.gastro.2010.07.052) Copyright © 2010 AGA Institute Terms and Conditions