International Toxicity Estimates for Risk (ITER) Database A Tool to Compare Chronic Human Health Risk Values Across Organizations A. Wullenweber1, A. Maier1, P. Wexler2, D. Rak3 & C. Tomljanovic4 1Toxicology Excellence for Risk Assessment (TERA); 2National Library of Medicine; 3Noblis; 4Concurrent Technologies Corporation Toxicology & Risk Assessment Conference April 2007

What is ITER? Free Internet database of human health chronic risk values from organizations around the world for 640+ chemicals. ITER provides: Risk value data in a side-by-side table format The underlying basis and rationale for each risk value A synopsis that explains differences in risk values A link to each organization’s website or source document A forum through which independent parties can share their peer reviewed risk values A resource to ensure that risk managers do not “miss” useful data

Arsenic Search in All TOXNET Databases 10 records containing the word “arsenic” found in ITER

Search Retrieval for Arsenic, including Primary Record

Summary Table for Arsenic, Inorganic

Arsenic, Inorganic – Noncancer Oral Data

Toxicology & Risk Assessment Conference April 2007 Risk Information Exchange (RiskIE) A Database to Communicate In-Progress Risk Assessments A. Wullenweber1, O. Kroner1, A. Maier1, P. Wexler2, D. Rak3 & C. Tomljanovic4 1Toxicology Excellence for Risk Assessment (TERA); 2National Library of Medicine; 3Noblis; 4Concurrent Technologies Corporation Toxicology & Risk Assessment Conference April 2007

Why do we need RiskIE? To facilitate information exchange early in the process!   Chemical use has outpaced risk values – need to ensure we do not duplicate effort Risk assessment values vary across organizations – opportunity for information exchange early in process Risk Assessments receive intense review – so need to ensure that all sources of useful data have been tapped

www.allianceforrisk.org

RiskIE Project Submission