The Molecular Basis of Vascular Disorders

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Presentation transcript:

The Molecular Basis of Vascular Disorders Jeffrey A. Towbin, Brett Casey, John Belmont The American Journal of Human Genetics Volume 64, Issue 3, Pages 678-684 (March 1999) DOI: 10.1086/302303 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Genetic defects affect various stages of cardiovascular development. Mutants from zebrafish, mouse, and human relating to primary developmental processes or maintenance of the vascular system. A, Vasculogenesis and angiogenesis. B, Embryonic development of the vascular system. C, Obstruction of the left ventricular outflow tract leading to hypoplastic left heart syndrome. Note the small left ventricle (LV), atretic aortic and/or mitral valves, with aortic hypoplasia. The American Journal of Human Genetics 1999 64, 678-684DOI: (10.1086/302303) Copyright © 1999 The American Society of Human Genetics Terms and Conditions