Jean-Michel Pawlotsky, MD, PhD Clinics in Liver Disease

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Hepatitis C virus genetic variability: pathogenic and clinical implications Jean-Michel Pawlotsky, MD, PhD Clinics in Liver Disease Volume 7, Issue 1, Pages 45-66 (February 2003) DOI: 10.1016/S1089-3261(02)00065-X

Fig. 1 (A) Phylogenetic tree of hepatitis C virus (HCV) genotypes. The 6 types are numbered 1–6, and the subtypes are identified by lower-case letters. (B) The variants initially designated as types 7–11 are now included into types 3 and 6. (From Simmonds P. The origin and evolution of hepatitis viruses in humans. J Gen Virol 2001;82:693–712; with permission.) Clinics in Liver Disease 2003 7, 45-66DOI: (10.1016/S1089-3261(02)00065-X)

Fig. 1 (A) Phylogenetic tree of hepatitis C virus (HCV) genotypes. The 6 types are numbered 1–6, and the subtypes are identified by lower-case letters. (B) The variants initially designated as types 7–11 are now included into types 3 and 6. (From Simmonds P. The origin and evolution of hepatitis viruses in humans. J Gen Virol 2001;82:693–712; with permission.) Clinics in Liver Disease 2003 7, 45-66DOI: (10.1016/S1089-3261(02)00065-X)

Fig. 2 Distribution of the frequencies of phylogenetic distances among genotype 1b and genotype 3a strains circulating in industrialized countries, respectively [23]. Clinics in Liver Disease 2003 7, 45-66DOI: (10.1016/S1089-3261(02)00065-X)

Fig. 3 HVR1 consensus hydropathic pattern established from 1382 HVR1 sequences: o, n, i and v, mean hydrophobic, neutral, hydrophilic,and variable positions, respectively. G is a fully conserved glycine residue. The + signs indicate positions often occupied by basic residues [46]. Clinics in Liver Disease 2003 7, 45-66DOI: (10.1016/S1089-3261(02)00065-X)

Fig. 4 Evolution of HCV genotype distribution in French patients with chronic hepatitis C, according to the date of infection (From: Martino-Peignoux M, Roudot-Thoraval F, Mendel I, et al. Hepatitis C virus genotypes in France: relationship with epidemiology, pathogenicity and response to interferon therapy. J Viral Hepat 1999;6:435–43; with permission.). Clinics in Liver Disease 2003 7, 45-66DOI: (10.1016/S1089-3261(02)00065-X)