The origin of quasispecies: cause or consequence of chronic hepatitis C viral infection?  David G. Bowen, Christopher M. Walker  Journal of Hepatology  Volume 42, Issue 3, Pages 408-417 (March 2005) DOI: 10.1016/j.jhep.2004.12.013 Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

Fig. 1 A model of factors constraining the generation of escape mutations during HCV infection, and how the development of such viral variants might ultimately contribute to viral persistence. For the sake of clarity, only the response to a single CTL epitope has been included in the diagram. Containment of viral escape would clearly require CTL responses against a wide range of epitopes; conversely, in order for viral escape to occur, the accumulation of multiple escape mutants would likely be required. Journal of Hepatology 2005 42, 408-417DOI: (10.1016/j.jhep.2004.12.013) Copyright © 2004 European Association for the Study of the Liver Terms and Conditions