Amy F.T. Arnsten, Daeyeol Lee, Christopher Pittenger Cell

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Risky Business: The Circuits that Impact Stress-Induced Decision-Making Amy F.T. Arnsten, Daeyeol Lee, Christopher Pittenger Cell Volume 171, Issue 5, Pages 992-993 (November 2017) DOI: 10.1016/j.cell.2017.11.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Stress-Induced Changes in Decision-Making (A) Just like humans, rats exposed to chronic stress make more “high-reward but high-cost” choices. (B) Friedman et al. (2017) reveal changes in striatal circuits that contribute to altered decision-making. While it has been well established that stress weakens the “top-down” influence of the prefrontal cortex, this study revealed the consequences on striatal physiology, where reduction in feed-forward inhibition by fast-spiking interneurons led to stronger striatal output from the projection neurons in striosomes, driving more high-risk/high-reward choices. Cell 2017 171, 992-993DOI: (10.1016/j.cell.2017.11.004) Copyright © 2017 Elsevier Inc. Terms and Conditions