Macrophages Have a Grip on the Gut

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Macrophages Have a Grip on the Gut Massimo Locati Immunity Volume 41, Issue 1, Pages 11-13 (July 2014) DOI: 10.1016/j.immuni.2014.07.002 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Crosstalk of Muscularis Mucosae Macrophages and Enteric Neurons In the gut, muscularis propria macrophages are organized in layers between the longitudinal and circular muscles and the outer and the inner circular muscles. In these areas, macrophages establish a bidirectional interaction with enteric neurons, being sustained in their development by neuronal-derived CSF1 and by converse stimulating neuronal activity via BMP2 secretion. Enteric neurons then control gastrointestinal motility acting on smooth-muscle cells. Changes in the microbiome composition influence muscularis propria macrophages, which accordingly tune intestinal peristalsis acting on this network. Adapted from Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H. (2010). Ganong’s Review of Medical Physiology, 23rd Edition (New York: McGraw Hill Companies). Immunity 2014 41, 11-13DOI: (10.1016/j.immuni.2014.07.002) Copyright © 2014 Elsevier Inc. Terms and Conditions