Volume 117, Issue 6, Pages (December 1999)

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Volume 117, Issue 6, Pages 1370-1379 (December 1999) Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis Peter L.M. Jansen*, Sandra S. Strautnieks‡, Emmanuel Jacquemin§, Michelle Hadchouel§, Etienne M. Sokal∥, Guido J.E.J. Hooiveld*, Johan H. Koning*, Alie de Jager-Krikken*, Folkert Kuipers¶, Frans Stellaard¶, Charles M.A. Bijleveld¶, Annette Gouw#, Harry van Goor#, Richard J. Thompson‡, Michael Müller* Gastroenterology Volume 117, Issue 6, Pages 1370-1379 (December 1999) DOI: 10.1016/S0016-5085(99)70287-8 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Western blot analysis of BSEP in canalicular subfractions from humans, mice, and rats using rabbit immunoglobulin G anti-BSEP antibodies. Samples from liver subfractions enriched in canalicular membranes were subjected to Western blot analysis. Gastroenterology 1999 117, 1370-1379DOI: (10.1016/S0016-5085(99)70287-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Localization of BSEP and MRP2 in normal liver. Staining with BSEP antibody (Control-1); staining with MRP2 antibody (Control-2). Gastroenterology 1999 117, 1370-1379DOI: (10.1016/S0016-5085(99)70287-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Localization of BSEP and MRP2 in liver sections of PFIC patients from the Groningen center. Staining for BSEP is shown in panels A-1 to E-1, staining for MRP2 in panels A-2 to E-2. The letters denote the various patients (Table 1). Gastroenterology 1999 117, 1370-1379DOI: (10.1016/S0016-5085(99)70287-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Localization of BSEP and MRP2 in liver sections of PFIC patients from the Groningen center. Staining for BSEP is shown in panels A-1 to E-1, staining for MRP2 in panels A-2 to E-2. The letters denote the various patients (Table 1). Gastroenterology 1999 117, 1370-1379DOI: (10.1016/S0016-5085(99)70287-8) Copyright © 1999 American Gastroenterological Association Terms and Conditions