Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils by Franziska Jundt, Ioannis Anagnostopoulos,

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Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils by Franziska Jundt, Ioannis Anagnostopoulos, Kurt Bommert, Florian Emmerich, Gerd Müller, Hans-Dieter Foss, Hans-Dieter Royer, Harald Stein, and Bernd Dörken Blood Volume 94(6):2065-2071 September 15, 1999 ©1999 by American Society of Hematology

Immunohistology of HD tissues. Immunohistology of HD tissues. Immunohistology of frozen sections of nodular sclerosis subtype of HD stained for eotaxin using a monoclonal anti-eotaxin antibody (red reaction product-APAAP technique). (A and B) Eotaxin-expressing cells are located within the collagen tissue bands. Hodgkin/Reed-Sternberg cells and other reactive cells are eotaxin negative. (C) Double labeling for CD3 (brown reaction product-streptavidin/biotin method) and eotaxin in a case of nodular sclerosing classical HD shows that most of the spindle-shaped eotaxin-expressing cells do not coexpress CD3. Franziska Jundt et al. Blood 1999;94:2065-2071 ©1999 by American Society of Hematology

In situ hybridization of HD lymph nodes. In situ hybridization of HD lymph nodes. In situ hybridization with eotaxin antisense probe is shown. Eotaxin-specific signals are found around blood vessels. Labeled cells were also observed in the cellular infiltrates. Using morphology, these cells may represent fibroblasts or, in some cases, macrophages (solid arrow). Franziska Jundt et al. Blood 1999;94:2065-2071 ©1999 by American Society of Hematology

Expression of the chemoattractant eotaxin in Hodgkin cell lines. Expression of the chemoattractant eotaxin in Hodgkin cell lines. Northern blot analysis of total RNA (30 μg) isolated from the Hodgkin cell lines HD-MyZ (lane 1), L1236 (lane 2), L428 (lane 3), and L591 (lane 4). The blot was hybridized with eotaxin- and subsequently with GAPDH-specific cDNA probes. Franziska Jundt et al. Blood 1999;94:2065-2071 ©1999 by American Society of Hematology

Induction of eotaxin mRNA expression in normal human dermal fibroblasts. Induction of eotaxin mRNA expression in normal human dermal fibroblasts. Northern blot analysis of total RNA (10 μg) isolated from fibroblasts. Blots were hybridized with eotaxin- and subsequently with GAPDH-specific probes. (A) Untreated fibroblasts (lane 1), fibroblasts after stimulation with 30 ng/mL TNF- (lane 2), and fibroblasts after cocultivation with the Hodgkin cell lines L1236 (lane 3), L428 (lane 4), KM-H2 (lane 5), and the pre-B–cell line Blin-1 (lane 6). (B) Fibroblasts after stimulation with 10 ng/mL TNF- (lanes 1 and 2) and incubation with anti–TNF- antibodies (lane 2). Fibroblasts after cultivation in supernatant of the Hodgkin cell line L1236 (lanes 3 and 4) and incubation with anti–TNF- antibodies (lane 4). Franziska Jundt et al. Blood 1999;94:2065-2071 ©1999 by American Society of Hematology

Eotaxin protein levels of cell supernatants. Eotaxin protein levels of cell supernatants. Eotaxin protein was measured by ELISA in supernatants of fibroblasts after stimulation with 30 ng/mL TNF- or cocultivation with the Hodgkin cell lines (L1236, L428, and KM-H2) and the pre-B–cell line (Blin-1). Errors are shown as the standard deviation. Franziska Jundt et al. Blood 1999;94:2065-2071 ©1999 by American Society of Hematology

Franziska Jundt et al. Blood 1999;94:2065-2071 ©1999 by American Society of Hematology

Franziska Jundt et al. Blood 1999;94:2065-2071 ©1999 by American Society of Hematology