Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2.

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Presentation transcript:

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta- analysis of controlled clinical trials Daniel R. Morales, MBChB, Brian J. Lipworth, MD, Bruce Guthrie, PhD, Cathy Jackson, MD, Peter T. Donnan, PhD, Virginia H. Santiago, MBBM Journal of Allergy and Clinical Immunology Volume 134, Issue 1, Pages 40-45.e10 (July 2014) DOI: 10.1016/j.jaci.2013.10.057 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 PRISMA flow diagram for study selection. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Respiratory symptoms after acute selective NSAID or COX-2 inhibitor exposure in patients with AERD. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Decrease in FEV1 of 20% or greater after acute selective NSAID or COX-2 exposure in patients with AERD. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Nasal symptoms after acute selective NSAID or COX-2 exposure in patients with AERD. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Respiratory symptoms after acute selective NSAIDs or COX-2 inhibitors in patients with AERD according to leukotriene antagonist exposure status. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Decreases in FEV1 of 20% or greater after acute selective NSAIDs or COX-2 inhibitors in patients with AERD according to leukotriene antagonist exposure status. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Nasal symptoms after acute selective NSAIDs or COX-2 inhibitors in patients with AERD according to leukotriene antagonist exposure status. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Respiratory symptoms after acute selective NSAIDs or COX-2 inhibitors in patients with AERD according to random allocation. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Decreases in FEV1 of 20% or greater after acute selective NSAIDs or COX-2 inhibitors in patients with AERD according to random allocation. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Nasal symptoms after acute selective NSAIDs or COX-2 inhibitors in patients with AERD according to random allocation. M-H, Mantel-Haenszel. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E7 Risk of bias table for included studies. Journal of Allergy and Clinical Immunology 2014 134, 40-45.e10DOI: (10.1016/j.jaci.2013.10.057) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions