National GI Tumor Board Clinical Investigators Provide Their Perspectives on Current Cases of Gastrointestinal Cancer Friday, January 21, 2011 7:00 PM – 9:30 PM San Francisco, California Moderator Neil Love, MD Faculty Charles D Blanke, MD David Cunningham, MD Steven A Curley, MD Eileen M O’Reilly, MD Eric Van Cutsem, MD, PhD Andrew X Zhu, MD, PhD 1 1

Case presented by Dr Schwartz 84 yo woman with bowel obstrux/perforation from sigmoid colon CA 12/05  extensive resection (T4N0) — K-Ras status not obtained 2/06: Post op CEA  5.8 and scan = R hepatic lesion Biopsy confirmed met CA Refused resection, started on capecitabine Dose redux/treatment delays through 8/06  f/u PET/CT = NED and CEA <2 Patient given “treatment holiday”

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Case presented by Dr Schwartz 84 yo woman with bowel obstrux/perforation from sigmoid colon CA 12/05  extensive resection (T4N0) — K-Ras status not obtained 2/06: Post op CEA  5.8 and scan = R hepatic lesion Biopsy confirmed met CA Refused resection, started on capecitabine Dose redux/treatment delays through 8/06  f/u PET/CT = NED and CEA <2 Patient given “treatment holiday”

National GI Tumor Board Clinical Investigators Provide Their Perspectives on Current Cases of Gastrointestinal Cancer Friday, January 21, 2011 7:00 PM – 9:30 PM San Francisco, California Moderator Neil Love, MD Faculty Charles D Blanke, MD David Cunningham, MD Steven A Curley, MD Eileen M O’Reilly, MD Eric Van Cutsem, MD, PhD Andrew X Zhu, MD, PhD 5 5

Are we ready to restrict EGFR therapy to quadruple-negative colorectal cancer? Eliza Hawkes, David Cunningham. Lancet Oncol 2010. 11(11):1020-21

National GI Tumor Board Clinical Investigators Provide Their Perspectives on Current Cases of Gastrointestinal Cancer Friday, January 21, 2011 7:00 PM – 9:30 PM San Francisco, California Moderator Neil Love, MD Faculty Charles D Blanke, MD David Cunningham, MD Steven A Curley, MD Eileen M O’Reilly, MD Eric Van Cutsem, MD, PhD Andrew X Zhu, MD, PhD 7 7

Case presented by Dr Schwartz 84 yo woman with bowel obstrux/perforation from sigmoid colon CA 12/05  extensive resection (T4N0) — K-Ras status not obtained 2/06: Post op CEA  5.8 and scan = R hepatic lesion Biopsy confirmed met CA Refused resection, started on capecitabine Dose redux/treatment delays through 8/06  f/u PET/CT = NED and CEA <2 Patient given “treatment holiday”