12/30/2018 OSTEOPOROSIS.

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Presentation transcript:

12/30/2018 OSTEOPOROSIS

the structure and function There is more than one gene responsible for the structure and function of the skeleton 12/30/2018 OSTEOPOROSIS

Scientists discovered a novel gene responsible for high bone density Oct 2001 - ASBMR news release Scientists discovered a novel gene responsible for high bone density At Creighton, we were fortunate to recognize and recruit this family with high bone mass …. R. Recker, M.D 12/30/2018 OSTEOPOROSIS

A Mutation in the LRP5 Gene Results in the Autosomal Dominant High Bone-Mass Trait Jan 2002; 70:11-19 12/30/2018 OSTEOPOROSIS

Y. Gong et al. (The Osteoporosis-Pseudoglioma Syndrome Collaborative Group), LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell Nov 2001;107: 513-523 12/30/2018 OSTEOPOROSIS

… the genetic trait that causes higher-than-normal bone density … maps to the same genomic region that contains LRP5 12/30/2018 OSTEOPOROSIS