The clonal selection model of immunogenesis

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The clonal selection model of immunogenesis

Cell division and gene rearrangement Figure 43.UN02 Stem cell Cell division and gene rearrangement Elimination of self-reactive B cells Antigen Clonal selection Formation of activated cell populations Antibody Plasma cells Memory B cells Pathogen Receptors bind to antigens

(b) Antigen receptor specificity Figure 43.10b Antibody C Antibody A Antibody B Antigen (b) Antigen receptor specificity

The common pathway of specific immunity

T cell antigen receptor Variable regions V V Figure 43.11 Antigen- binding site T cell antigen receptor Variable regions V V C C Constant regions Disulfide bridge Transmembrane region  chain  chain Plasma membrane T cell Cytoplasm of T cell

Docking, then activation by interleukins Cellular immunity

Lysis of infected cell by activated T – cytotoxic lymphocyte

The primary and secondary responses IgM IgG

Overview of specific immunity

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