Viral genomes and Eukaryotic Virus Growth

Figure 6.20 5

Picornavirus (RNA) Life Cycle Figure 6.23 8

The poliovirus binds to poliovirus receptor (PVR) through its VP2 and VP3 subunits. - A conformational change in VP1 allows insertion of the genome into the cytoplasm. Figure 11.12 9

Poliovirus Replication In the cytoplasm, the RNA is translated to make three large precursor peptides: P1–3. - All three peptides are eventually cleaved by proteases to generate 11 proteins. Figure 11.13A 10

Influenza Virus Structure The flu virus has no geometric capsid. RNA genome is loosely contained by a shell of matrix proteins. Figure 11.16 RNA segments are coated with nucleocapsid proteins (NPs). Two major envelope proteins: - Neuraminidase (NA) - Hemagglutinin (HA) 11

The Genome of Influenza A Virus Figure 11.17 14

- Instant new strain can evade the immune system. The key advantage of a segmented genome is that it facilitates recombination between two strains coinfecting the same cell. - Instant new strain can evade the immune system. Figure 11.18B 15

Figure 11.21 16

Reo virus ds RNA

Herpes Simplex Virus Structure An icosahedral capsid houses the dsDNA genome. Capsid is surrounded by a protein tegument, which is contained within an envelope with spike proteins. Figure 11.31A 18

Figure 11.32 19

Fig. 19-11 tRNA-like structure Stop codon Cap MTH RNP MP CP

Figure 6-6 Viroids: infective RNA. sfmb2e_0606.jpg

Figure 6-7 Prion disease. sfmb2e_0607.jpg