SB Size: 10 mg M.W.= Batch No.: 1A/ Description:

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SB 203580 Size: 10 mg M.W.=377.44 Batch No.: 1A/2004002 Description: Cat # PKI-SB203-010 15875 Gaither Drive Gaithersburg, MD 20877 FAX. 301-560-4919 TEL. 301-330-5966 Toll Free. 1-866-918-6812 Email: info@signagenlabs.com Web: www.signagenlabs.com This product is for laboratory research ONLY and not for diagnostic use Description: SB203580 is a highly selective and cell permeable inhibitor of p38 mitogen-activated protein kinase with IC50 values of 50 and 500 nM for p38/SAPK2a and p38/SAPK2b respectively. Also inhibits the phosphoinositide-dependent protein kinase 1 (PDK1) at 10-fold higher concentrations (IC50 ~3-5 µM). Displays 100-500-fold selectivity over Lck, GSK3b and Akt/PKB. Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2 and thromboxane synthase. PHYSICAL AND CHEMICAL PROPERTIES Batch Molecular Formula: C21H16FN3OS Batch Molecular Weight: 377.44 CAS No: [152121-47-6] Physical Appearance: White solid Melting Point (°C): 249 - 250 Solubility: DMSO to 25 mM 1eq. HCl to 100 mM ANALYTICAL DATA TLC: R f = 0.23 (Dichloromethane:Methanol [10:1]) HPLC: Shows 100% purity 1 H NMR: Consistent with authentic reference material Molecular Structure References: 1. Cuenda et al (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364 229. 2. Saklatvala et al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J. Biol. Chem. 271 6586. 3. Borsch-Haubold et al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J. Biol. Chem. 273 28766. 4. Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351 95. Storage: Desiccate at +4°C . Product shipped at ambient temperature.  2006 SignaGen Laboratories