The predictive value of s-cystatin C for mortality after coronary artery bypass surgery Alain Dardashti, MD, PhD, Shahab Nozohoor, MD, PhD, Lars Algotsson,

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Presentation transcript:

The predictive value of s-cystatin C for mortality after coronary artery bypass surgery Alain Dardashti, MD, PhD, Shahab Nozohoor, MD, PhD, Lars Algotsson, MD, PhD, Per Ederoth, MD, PhD, Henrik Bjursten, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 152, Issue 1, Pages 139-146 (July 2016) DOI: 10.1016/j.jtcvs.2016.02.070 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Area under the curve (AUC) comparison between preoperative s-cystatin C, s-creatinine, their corresponding GFR estimates, and the combined GFR estimate of s-creatinine and s-cystatin C for overall mortality. CKD-EPI, Chronic Kidney Disease-Epidemiology; CyC, cystatin C; eGFR, estimated glomerular filtration rate; creat, creatinine; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 139-146DOI: (10.1016/j.jtcvs.2016.02.070) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Preoperative s-cystatin C quintiles and all-cause mortality. Cutoff points for s-cystatin C quintiles are <0.91, 0.91 to 1.02, 1.02 to 1.15, 1.15 to 1.35, and >1.35 mg/L. For comparison among quintiles, there were significant differences among quintiles 1, 2, and 4 (log-rank P < .01) and among quintiles 1, 2, 3, 4, and 5 (log-rank P < .001). The Journal of Thoracic and Cardiovascular Surgery 2016 152, 139-146DOI: (10.1016/j.jtcvs.2016.02.070) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Forest plot for preoperative different GFR estimates and 2 to -5-year mortality with HR (95% CI). HR values <1 are due to the indirect relationship of eGFR and postoperative mortality, with lower eGFR related to higher mortality. CAPA, Caucasian and Asian Pediatric and Adult subjects; CyC, cystatin C; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease-Epidemiology; creat, creatinine; MDRD, Modification of Diet in Renal Disease formula; HR, hazard ratio. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 139-146DOI: (10.1016/j.jtcvs.2016.02.070) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Area under the curvecomparison between preoperative s-cystatin C, s-creatinine, and their corresponding GFR estimates for mortality. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 139-146DOI: (10.1016/j.jtcvs.2016.02.070) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions