Bioscience-Based Economic Development: Innovation and Investment in UCONN Mostafa Analoui, PhD Executive Director of UConn Venture Development Adj. Professor of Biomedical Engineering & Entrepreneurship

Life Expectancy & Health Spending per capita, 2013 Source: OECD Health Statistics 2015, http://dx.doi.org/10.1787/health-data-en

Quality of Death Economist Intelligence Unit (EIU) published its report: “The 2015 Quality of Death Index”

Expenditure on retail pharmaceuticals per capita and as a share of GDP, 2013 Sources: http://dx.doi.org/10.1787/888933280639

Where is the Waste? Source: https://www.washingtonpost.com/news/wonk/wp/2014/12/03/heres-exactly-how-the-united-states-spends-2-9-trillion-on-health-care/?utm_term=.f57f046196f0

Drug Development is Hard (2016 PhRMA)

R&D Investment as % of Sales Source: Pham ND; NDP Analytics. IP-intensive manufacturing industries: driving US economic growth. http://www.ndpanalytics.com/ip-intensive-manufacturing-industries-driving-useconomic- growth-2015. Published March 2015. Accessed March 2016.

Biotech Ecosystem & Equilibrium 12/30/2018 Biotech Ecosystem & Equilibrium $NIH$ University, Corporate Discovery Early Stage Biotech $Corporate R&D$ $Foundations$ Jobs Taxes Taxes Jobs Surviving Biotechs Jobs Taxes Jobs IPO Jobs Products in Market Taxes Deal

CT Biomedical Research and Innovation

Employment Across Sectors Source: Connecticut’s Economic Development Strategy , Spring 2014

Diversity of CT Bioscience Subsectors Batelle/BIO State Bioscience Jobs, Investments and Innovation, 2014; Economic Digest, 2012;, Economic Modeling Specialists, Inc. 2016; CERC calculations

Unique Biomedical Eco-System Higher Education Corporate R&D Clinical Excellence Bioscience CT Initiative Generating long term, sustainable economic growth based on bioscience research, innovation, entrepreneurship and commercialization JAX Connecticut Innovation

UCONN RESEARCH & SCHOLARSHIP: DRIVING RESEARCH SUCCESS Initiatives & Investments Bioscience Connecticut – UConn Health $864 million investment in genomics and personalized medicine The Jackson Laboratory for Genomic Medicine located at UConn Health campus Infrastructure projects, including research lab renovations, outpatient pavilion, tech incubator addition, and academic building improvements Goal set to hire 50 new basic science/clinical faculty

UCONN RESEARCH & SCHOLARSHIP: RESEARCH & DISCOVERY (Storrs/Regionals and UConn Health) Over $260M annually in competitive grants from external sponsors and internal programs to: Fund groundbreaking basic and applied research Fuel new discoveries Develop promising technologies Support important scholarship & creative projects Over 1,900 faculty fuel UConn and UConn Health’s growing research enterprise.

UConn Research Centers and Institues UConn is home to over eighty-five Centers and Institutes that have been established to promote scholarly activity and/or support teaching, research, diversity or the outreach mission of the institution. New/Growing Research Centers & Institutes (Sample) National Bio-NMR (nuclear magnetic resonance) Center at UConn Health Single Cell Genomics Center (joint UConn/JAX) Institute for Collaboration on Health, Intervention, and Policy (InCHIP) Rudd Center for Food Policy & Obesity CT Institute for the Brain and Cognitive Sciences Institute for Systems Genomics Center on Aging Humanities Institute CT Institute for Clinical & Translational Science

Entrepreneurship in UConn

Multidisciplinary and Team Sport

UConn Entrepreneurship Funds and Awards* * Selective list

Technology Incubation Program (TIP) - Industry Mix UConn TIP Aerospace, Transportation & Defense Consumer Products/ Animal Health Green Technology & Green Energy Biotech & Medical Devices IT & Software Development Nanotechnology & Advanced Manufacturing

TIP Sample Portfolio Companies BioPharma Works 3D Array IC3D Thetis Pharma Avitus Orthopaedics Azitra Bioarray Genetics CaroGen Connecticut Children’s Medical Center Diameter Health Frequency Therapeutics Health eSense Cornovus Atlas Labs Mobile Sense Technologies Oral Fluid Dynamics ImStem Biotechnology Lambda Vision Inc. Lipid Genomics mBiotics Medisynergics Mitotherapeutix Inc. Nervomatrix Reinesse Shoreline Biome Torigen Agrivida Biorasis DuraBiotech Mattershift Technology HiFunda MedFrame Solutions Spray Technologies

Technology Incubation Program (TIP) Venture Funding Notes: D&E 2016 – Agrivida $21M, Frequency $9M, Diameter $2M, CaroGen $2M; 2015 Agrivida $11M; 2014 Agrivida $13M, Nagare $11M

Innovation Partnership Building (IPB) Targets Manufacturers Attracts Large Corporations Supports Small and Medium-Sized Enterprises in Supply Chain Aligning Industry needs with UConn innovation and expertise Systems Engineering Advanced Manuf. & Materials Energy Engineering Biomedical Engineering & Sciences The Innovation Partnership Building (IPB) connects industry partners and faculty experts in state-of-the-art labs to fuel scientific breakthroughs, advance new products and create high-paying jobs.