Polymorphism of Interleukin-23 Receptor Gene But Not of NOD2/CARD15 Is Associated with Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation.

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Presentation transcript:

Polymorphism of Interleukin-23 Receptor Gene But Not of NOD2/CARD15 Is Associated with Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation in Children Bernd Gruhn, Juliane Intek, Nadine Pfaffendorf, Roland Zell, Selim Corbacioglu, Felix Zintl, James F. Beck, Klaus-Michael Debatin, Daniel Steinbach Biology of Blood and Marrow Transplantation Volume 15, Issue 12, Pages 1571-1577 (December 2009) DOI: 10.1016/j.bbmt.2009.08.001 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 The IL23R-1142 G>A allele in the donor is associated with less severe and less frequent GVHD (Spearman correlation P=.024). Donor IL23R-1142 G>A positive, n=20; donor IL23R-1142 G>A negative, n=161. Biology of Blood and Marrow Transplantation 2009 15, 1571-1577DOI: (10.1016/j.bbmt.2009.08.001) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Polymorphisms of IL23R and NOD2/CARD15 are not associated with OS after stem cell transplantation in children. (A) Patient IL23R-1142 G>A positive (n=17) versus patient IL23R-1142 G>A negative (n=200). (B) Donor IL23R-1142 G>A positive (n=20) versus donor IL23R-1142 G>A negative (n=161). (C) Patient positive for any of the 3 SNPs in NOD2/CARD15 (n=41) versus patient negative for all 3 SNPs (n=176). (D) Donor positive for any of the 3 SNPs in NOD2/CARD15 (n=33) versus patient negative for all 3 SNPs (n=148). Biology of Blood and Marrow Transplantation 2009 15, 1571-1577DOI: (10.1016/j.bbmt.2009.08.001) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions