Fig. 2 Activity-dependent dynamics of β-actin mRNP in neurons from MCP×MBS mouse.(A and B) Examples of β-actin mRNP merge (A) and split (B) events. Activity-dependent.

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Fig. 2 Activity-dependent dynamics of β-actin mRNP in neurons from MCP×MBS mouse.(A and B) Examples of β-actin mRNP merge (A) and split (B) events. Activity-dependent dynamics of β-actin mRNP in neurons from MCP×MBS mouse.(A and B) Examples of β-actin mRNP merge (A) and split (B) events. From top to bottom: initial images of the particles, kymographs during a 12-s period, and final images. (C) Ratio of split to merge events increased after KCl depolarization (n = 11 neurons from three cultures, 14 to 16 days in vitro; P < 0.05 by t test). (D) CA1 region in acute hippocampal slice. Scale bar, 50 μm. (E) Soma layer of CA1 neurons. Panels show maximum projections of x-y, y-z, and x-z planes. Scale bar, 10 μm. (F) Transcription of β-actin gene with KCl depolarization. Arrowheads denote β-actin transcription sites. Scale bar, 5 μm. (G) Nascent mRNA per transcription site increased after depolarization (n = 86 sites, brain slices from 3 mice; P < 0.001 by pairwise t test). Error bars denote SEM. H Y Park et al. Science 2014;343:422-424 Published by AAAS