Volume 120, Issue 5, Pages 1203-1211 (April 2001) ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism  Wolfgang Drobnik, Bernhard Lindenthal, Bernd Lieser, Mirko Ritter, Trudy Christiansen Weber, Gerhard Liebisch, Uwe Giesa, Michael Igel, Hana Borsukova, Christa Büchler, Wai Ping Fung–Leung, Klaus Von Bergmann, Gerd Schmitz  Gastroenterology  Volume 120, Issue 5, Pages 1203-1211 (April 2001) DOI: 10.1053/gast.2001.23250 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Fecal excretion of different bile acid species. Bile acids in stool samples were analyzed as described in Material and Methods. Data (mean ± SD) are from 9 ABCA1+/+ (■) and 10 ABCA1−/− (▩) mice. DCA, deoxycholic acid; βMCA, β-muricholic acid; ωMCA, ω-muricholic acid; CDCA, chenodeoxycholic acid; UDCA, ursodeoxycholic acid; LCA, lithocholic acid; CA, cholic acid; aωMCA, allo-ω-muricholic acid. Gastroenterology 2001 120, 1203-1211DOI: (10.1053/gast.2001.23250) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 HMG-CoA reductase and HMG-CoA synthase expression in the liver. A representative Northern blot analysis of mRNA expression of the indicated enzymes in the liver from 2 wild-type and 2 ABCA1 mice. GAPDH, glyceraldehyde 3-phosphate dehydrogenase. Gastroenterology 2001 120, 1203-1211DOI: (10.1053/gast.2001.23250) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 (A) SR-BI mRNA expression in the liver. A representative Northern blot analysis from 2 wild-type and 2 ABCA1-deficient mice. (B) SR-BI protein expression in the liver. A representative Western blot analysis from liver homogenates of ABCA1+/+ and ABCA1−/− mice. Gastroenterology 2001 120, 1203-1211DOI: (10.1053/gast.2001.23250) Copyright © 2001 American Gastroenterological Association Terms and Conditions