Desmoplasia of Pancreatic Ductal Adenocarcinoma

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Presentation transcript:

Desmoplasia of Pancreatic Ductal Adenocarcinoma Stephen Pandol, Mouad Edderkaoui, Ilya Gukovsky, Aurelia Lugea, Anna Gukovskaya Clinical Gastroenterology and Hepatology Volume 7, Issue 11, Pages S44-S47 (November 2009) DOI: 10.1016/j.cgh.2009.07.039 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Components of desmoplasia in PDAC. Pancreatic cancer cells and pancreatic duct cells promote each others' growth and proliferation and together regulate processes of ECM deposition, angiogenesis, and disordered immune surveillance. Clinical Gastroenterology and Hepatology 2009 7, S44-S47DOI: (10.1016/j.cgh.2009.07.039) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 ROS promote the pancreatic cancer cell phenotype. ROS from both desmoplasia and through desmoplasia stimulation of cancer cells through cytokines, growth factors, and ECM proteins mediate the pancreatic cancer cell phenotype. Clinical Gastroenterology and Hepatology 2009 7, S44-S47DOI: (10.1016/j.cgh.2009.07.039) Copyright © 2009 AGA Institute Terms and Conditions