EXCITE ISR Trial design: Participants with femoropopliteal in-stent restenosis were randomized to excimer laser atherectomy + adjunctive angioplasty (n = 169) vs. angioplasty alone (n = 81). Results (p < 0.005) Freedom from target lesion revascularization (TLR) at 6 months: 73.5% of the laser group vs. 51.8% of the angioplasty alone group (p < 0.005) Freedom from major adverse events 30 days: 94.2% of the laser group vs. 79.2% of the angioplasty alone group (p < 0.001) 73.5 % 51.8 Conclusions Among patients with femoropopliteal in-stent restenosis, the use of excimer laser plus angioplasty was superior compared with angioplasty alone Acute procedural success was higher in the atherectomy group Excimer laser plus angioplasty Angioplasty alone Presented by Dr. Eric Dippel at TCT 2014