Volume 115, Issue 5, Pages 1066-1071 (November 1998) Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16  Mark E. Curran*, Kit F. Lau*, Jochen Hampe‡, Stefan Schreiber‡, Steven Bridger§, Andrew J.S. Macpherson§, Lon R. Cardon*, Hakan Sakul*, Timothy J.R. Harris*, Pieter Stokkers∥, Sander J.H. van Deventer∥, Mudassar Mirza¶, Andreas Raedler#, Wolfgang Kruis**, Ullrich Meckler‡‡, Dieter Theuer§§, Torsten Herrmann∥∥, Paolo Gionchetti¶¶, John Lee##, Chris Mathew¶, John Lennard-Jones##  Gastroenterology  Volume 115, Issue 5, Pages 1066-1071 (November 1998) DOI: 10.1016/S0016-5085(98)70075-7 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Multipoint MLS curves for (A) chromosome 12 and (B) chromosome 16. Multipoint analyses were performed using the MAPMAKER/SIBS program. Results for CD (thick solid line), UC (thin solid line), and all pairs (dashed line) are shown. Genetic distances between markers, estimated from the data set, are shown in Table 2. Marker allele frequencies were calculated from the full sample. Average heterozygosity was 0.77 for chromosome 12 (range, 0.52–0.92) and 0.76 for chromosome 16 (range, 0.65–0.84). Gastroenterology 1998 115, 1066-1071DOI: (10.1016/S0016-5085(98)70075-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Multipoint MLS curves for (A) chromosome 12 and (B) chromosome 16. Multipoint analyses were performed using the MAPMAKER/SIBS program. Results for CD (thick solid line), UC (thin solid line), and all pairs (dashed line) are shown. Genetic distances between markers, estimated from the data set, are shown in Table 2. Marker allele frequencies were calculated from the full sample. Average heterozygosity was 0.77 for chromosome 12 (range, 0.52–0.92) and 0.76 for chromosome 16 (range, 0.65–0.84). Gastroenterology 1998 115, 1066-1071DOI: (10.1016/S0016-5085(98)70075-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions