Lymphoma spread? Target CD47-SIRPα!

Slides:

Advertisements

Similar presentations

Egress of CD19 + CD5 + cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients.

Advertisements

Lymphoma dissemination: the other face of lymphocyte homing by Steven T. Pals, David J. J. de Gorter, and Marcel Spaargaren Blood Volume 110(9):

A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies by Jutta Deckert, Peter U. Park,

The β2 integrin–kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo by Vicky Louise Morrison, Matthew MacPherson,

The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase–dependent cleavage of calreticulin in AML patients by Sarah Mans, Yara Banz,

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration by Ayako Nakamura-Ishizu,

CC Chemokine Receptor 5 and CXC Chemokine Receptor 6 Expression by Lung CD8+ Cells Correlates with Chronic Obstructive Pulmonary Disease Severity Christine.

Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo by Ilze Bot, Jian Guo, Miranda Van Eck,

Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B- cell lymphomas by Lingchen Fu, Yen-Chiu Lin-Lee,

Sperm protein 17 (Sp17) is a suitable target for immunotherapy of multiple myeloma by Maurizio Chiriva-Internati, Zhiqing Wang, Emanuela Salati, Klaus.

Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells by Jonathan M. Irish,

The Prognostic Value Of Dynamic Monitoring C-Reactive Protein (CRP) Serum Levels In NK/T-Cell Lymphoma by Bing Bai, Qi-chun Cai, Xiao-Xiao Wang, Qingqing.

Gene therapy: efficient targeting of hematopoietic stem cells

Elevated Serum CD44 Level Is Associated With Unfavorable Outcome in Non-Hodgkin's Lymphoma by Raija Ristamäki, Heikki Joensuu, Kimmo Lappalainen, Lasse.

Figure 1 CTLA-4 and PD-1–PD-L1 immune checkpoints

CD146: a new partner for VEGFR2

Do HSCs divide asymmetrically?

EBV DNA: a Hodgkin lymphoma biomarker?

“Vitamin hypothesis”: explanation for allergy increase?

Fledgling prognostic markers in CLL

Mechanisms mediating the clinical activities of anti-PD-1/PD-L1/CTLA-4 antibodies. Mechanisms mediating the clinical activities of anti-PD-1/PD-L1/CTLA-4.

by Venetia Bigley, Laura E. Spence, and Matthew Collin

Yin and yang of glucocorticoid receptors in apoptosis

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

by Zhenping Zhu Blood Volume 108(6): September 15, 2006

Tax fingerprint in adult T-cell leukemia

Chemokine and Chemokine Receptor Gene Variants and Risk of Non-Hodgkin’s Lymphoma in Human Immunodeficiency Virus-1–Infected Individuals by Charles S.

Nonmyeloablative conditioning for relapsed follicular lymphoma

Mechanisms of HIV-associated lymphocyte apoptosis

SOX11 holds mantle cell lymphoma’s key to home

An Unusual Cause of Abdominal Pain in Sickle Cell Disease

Engineering regulatory T cells against factor VIII inhibitors

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses by Caroline Lemieux, Ricardo Maliba, Judith.

Lymphoma dissemination: the other face of lymphocyte homing

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Mutation Analysis of the Rearranged Immunoglobulin Heavy Chain Genes of Marginal Zone Cell Lymphomas Indicates an Origin From Different Marginal Zone B.

CD6 Ligation Modulates the Bcl-2/Bax Ratio and Protects Chronic Lymphocytic Leukemia B Cells From Apoptosis Induced by Anti-IgM by Lyda M. Osorio, Angelina.

Glucocorticoids Induce Kaposi's Sarcoma Cell Proliferation Through the Regulation of Transforming Growth Factor-β by Jie Cai, Tong Zheng, Martin Lotz,

AIDS-Related Extranodal Non-Hodgkin's Lymphomas With Plasma Cell Differentiation by Antonino Carbone, Annunziata Gloghini, Vincenzo Canzonieri, Umberto.

Setting the table for macrophages

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy by Mark P. Chao, Chad Tang, Russell K. Pachynski,

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

Figure 4 Macrophage-targeting antitumour treatment approaches

Ph+ ALL: drawing strength from a benign past

How I treat refractory CLL

by George Z. Rassidakis, Mauricio P. Oyarzo, and L. Jeffrey Medeiros

Cytokine-Release Syndrome in Patients With B-Cell Chronic Lymphocytic Leukemia and High Lymphocyte Counts After Treatment With an Anti-CD20 Monoclonal.

Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells by Jonathan M. Irish,

A New Therapeutic Target for Leukemia Comes to the Surface

TIGIT and CD226: Tipping the Balance between Costimulatory and Coinhibitory Molecules to Augment the Cancer Immunotherapy Toolkit Kristen E. Pauken,

Molecular Therapy Volume 21, Pages S247-S248 (May 2013)

Erratum in Ledru et al. Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development.

Anti-CD20-IL-21 fusokine: the tail wags the dog

A new key in breast cancer metastasis

Morton J Cowan, Hans-Peter Kiem Molecular Therapy

Influence of the tumor microenvironment on FL

Mesenchymal Stem Cell-Derived Vesicles Reverse Hematopoietic Radiation Damage by Sicheng Wen, Laura R Goldberg, Mark S Dooner, John L Reagan, and Peter.

A binding relationship with thrombin

Expression of CRC stem cell markers and L1 in CRC cells.

Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma by Bethany Mundy-Bosse, Nathan Denlinger,

Hepatosplenic T-Cell Lymphoma: Clinicopathological Features and Treatment Outcomes: Report From The North American Peripheral T-Cell Lymphoma Consortium.

A, Natalizumab blocks the adhesion of leukocytes to endothelial cells by blocking the interaction of the α4-integrin subunit of α4β1 with VCAM-1 and of.

Expression of chemokine receptors in A-498 cell line.

Chimeric antigen receptor–modified T cells: CD19 and the road beyond

by Victor A. Chow, Mazyar Shadman, and Ajay K. Gopal

Is Skull-Base to Proximal Thigh PET/CT Enough

PD-1 expression and clinical PD-1 blockade in B-cell lymphomas

RANK ligand and osteoprotegerin in myeloma bone disease

A schematic diagram showing the mechanism by which L5 triggers platelet activation and aggregation. A schematic diagram showing the mechanism by which.

Presentation transcript:

Lymphoma spread? Target CD47-SIRPα! by Marcel Spaargaren Blood Volume 118(18):4762-4764 November 3, 2011 ©2011 by American Society of Hematology

CD47 is an integrin-associated protein and a ligand for the phagocytosis-inhibitory receptor SIRPα (left). CD47 is an integrin-associated protein and a ligand for the phagocytosis-inhibitory receptor SIRPα (left). Various types of NHL overexpress CD47, which correlates with poor prognosis. In this issue of Blood, Chao et al show that CD47 is more prominently expressed by disseminated lymphoma cells and that targeting CD47 with a blocking antibody or by RNAi impairs chemokine-controlled migration, promotes macrophage-mediated phagocytosis and prevents dissemination of the malignant B cells (right). Marcel Spaargaren Blood 2011;118:4762-4764 ©2011 by American Society of Hematology