Regional genome association plots for the GWAS results of the FADS1/2/3 region of chromosome 11. Regional genome association plots for the GWAS results.

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Regional genome association plots for the GWAS results of the FADS1/2/3 region of chromosome 11. Regional genome association plots for the GWAS results of the FADS1/2/3 region of chromosome 11. The horizontal red dashed line in each plot shows the −log 10 (experiment-wise significance rate). Panel A shows the unconditioned additive genetic model results for all tested SNPs (85)×all 33 breast milk fatty acid phenotypes in this region plotted as chromosome map position (bp) versus −log(P value) of the score test result from SNPTEST. Arachidonic acid phenotype results are highlighted in blue and the lead SNP in cyan. Panel B shows the same SNPs and genetic model, but with the addition of log(AA) as a covariate adjustment to condition on AA concentration in breast milk (AA phenotype results not shown). Panel C shows the same analyses but with the SNP genetic models conditioned on the lead SNP (rs174556) as a covariate. Panel D shows the hg19 local genome physical map with overlaid epigenetic tracks (UCSC browser). GWAS, genome wide association studies. Josyf C Mychaleckyj et al. J Med Genet 2018;55:459-468 ©2018 by BMJ Publishing Group Ltd