Volume 154, Issue 8, Pages 2068-2086.e5 (June 2018) The Effect of Endoscopic Surveillance in Patients With Barrett’s Esophagus: A Systematic Review and Meta-analysis  Don Chamil Codipilly, Apoorva Krishna Chandar, Siddharth Singh, Sachin Wani, Nicholas J. Shaheen, John M. Inadomi, Amitabh Chak, Prasad G. Iyer  Gastroenterology  Volume 154, Issue 8, Pages 2068-2086.e5 (June 2018) DOI: 10.1053/j.gastro.2018.02.022 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Preferred Reporting items for Systematic Reviews and Meta-analyses (PRISMA) flow diagram showing study selection. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Group 3: Reduction in EAC-related mortality. M-H, Mantel-Haenszel risk ratio. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Figure 3 Group 3: Reduction in all-cause mortality. GI, gastrointestinal; IV, instrumental variable; SE, standard error. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Figure 4 Group 4: Reduction in EAC-related mortality. diag, diagnosis; M-H, Mantel-Haenszel risk ratio. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Figure 5 All-cause mortality (with studies providing adjusted data). diag, diagnosis; GERD, gastroesophageal reflux disease; IV, instrumental variable; SE, standard error. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Figure 6 Sensitivity analysis: Lead time–adjusted overall mortality in group 4. IV, instrumental variable; SE, standard error. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 1 Group 3: Early Stage (Stage 0 and I) Diagnosis. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 2 Group 3: Surgical Resection and Esophagectomy rates. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 3 Group 4: Reduction in all-cause mortality (all studies included). Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 4 Group 4: Funnel Plot of Group 4: Reduction in all-cause mortality. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 5 Group 4: Early Stage (Stage 0 and I) Diagnosis. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 6 Surgical Resection and Esophagectomy rates. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 7 Sensitivity Analysis: Reduction in all-cause mortality in studies with pre-specified surveillance intervals. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 8 Overall mortality in studies from the initiation of BE surveillance. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 9 EAC-related mortality in studies from the initiation of BE surveillance. Gastroenterology 2018 154, 2068-2086.e5DOI: (10.1053/j.gastro.2018.02.022) Copyright © 2018 AGA Institute Terms and Conditions