Volume 3, Issue 6, Pages (November 2017)

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Volume 3, Issue 6, Pages 515-518 (November 2017) Stewart–Treves syndrome in a spinal cord injury patient with MYC amplification Andrew S. Fischer, MD, Christopher Rizk, MD, Leigh Sutton, MD, Bhuvaneswari Krishnan, MD, Ida Orengo, MD, Daniel N. Cohen, MD, PhD JAAD Case Reports Volume 3, Issue 6, Pages 515-518 (November 2017) DOI: 10.1016/j.jdcr.2017.07.004 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Rapidly growing and bleeding lesion above the ankle on the right lower leg. JAAD Case Reports 2017 3, 515-518DOI: (10.1016/j.jdcr.2017.07.004) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 The initial biopsy specimen reveals c-MYC amplification (8q24 probe red, centromere of chromosome 8 probe green) via fluorescence in situ hybridization, supporting the diagnosis of secondary angiosarcoma. JAAD Case Reports 2017 3, 515-518DOI: (10.1016/j.jdcr.2017.07.004) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Primary excision shows an invasive tumor with discontinuous lobules extending to the deep soft tissue. (Hematoxylin–eosin stain; original magnification: ×4.) JAAD Case Reports 2017 3, 515-518DOI: (10.1016/j.jdcr.2017.07.004) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Clusters of atypical tumor cells were noted at the margin of the primary excision (upper right and lower left). (Hematoxylin–eosin stain; original magnification: ×40.) JAAD Case Reports 2017 3, 515-518DOI: (10.1016/j.jdcr.2017.07.004) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Supplemental Figure 1 Invasive angiosarcoma forming vessels with leading edge single tumor cells and extravasated red blood cells in the initial biopsy specimen. (Hematoxylin–eosin stain; original magnification: ×20.) JAAD Case Reports 2017 3, 515-518DOI: (10.1016/j.jdcr.2017.07.004) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Supplemental Figure 2 Tumor cell nuclear reactivity with erythroblast transformation-specific related gene by immunohistochemical analysis, supporting the diagnosis of angiosarcoma. (Original magnification: ×10.) JAAD Case Reports 2017 3, 515-518DOI: (10.1016/j.jdcr.2017.07.004) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions