Volume 4, Issue 2, Pages (March 2018)

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Presentation transcript:

Volume 4, Issue 2, Pages 179-184 (March 2018) The coexistence of lupus erythematosus panniculitis and subcutaneous panniculitis-like T-cell lymphoma in the same patient Xinyu Wu, MD, PhD, Antonio Subtil, MD, MBA, Brittany Craiglow, MD, Kalman Watsky, MD, Asher Marks, MD, Christine Ko, MD JAAD Case Reports Volume 4, Issue 2, Pages 179-184 (March 2018) DOI: 10.1016/j.jdcr.2017.08.021 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Histopathology of discoid lupus erythematosus and lupus panniculitis on scalp. A, Hematoxylin-eosin stain shows periadnexal, dermal, and subcutaneous lymphocytic infiltrate. B, Hyaline necrosis in the fat with foci of lobular panniculitis. C, Epidermal atrophy and basement membrane zone thickening. D, Ki-67 highlighted scattered lymphocytes. E, CD123 highlighted clusters of plasmacytoid dendritic cells. F-H, The skin findings in scalp and forearm. JAAD Case Reports 2018 4, 179-184DOI: (10.1016/j.jdcr.2017.08.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histopathology of SPTCL on left forearm. A and B, PET-CT showed extensive neoplastic involvement throughout the body, especially lower extremities. C and D, Hematoxylin-eosin stain showed variably sized lymphocytes infiltrating subcutaneous adipose tissue. Atypical mitoses and rimming of adipocytes were identified. Involvement of epidermis or dermis was absent. E-M, The infiltrate consisted of αβ cytotoxic T cells (CD3+/CD20−/CD4−/CD8+/CD5+/CD45RO+/βF1+/TIA1+). JAAD Case Reports 2018 4, 179-184DOI: (10.1016/j.jdcr.2017.08.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Histopathology of recurrent lupus erythematosus on scalp. A and B, Hematoxylin-eosin stain shows superficial and deep lymphocytic infiltrate with perieccrine and perifollicular accentuation. C and D, CD4 highlighted more lymphocytes than CD8. JAAD Case Reports 2018 4, 179-184DOI: (10.1016/j.jdcr.2017.08.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions