In Epilepsy, BAD Is Not Really Bad

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Presentation transcript:

In Epilepsy, BAD Is Not Really Bad Elena Ziviani, Luca Scorrano  Neuron  Volume 74, Issue 4, Pages 600-602 (May 2012) DOI: 10.1016/j.neuron.2012.05.003 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 BAD Phosphorylation Controls Mitochondrial Fuel Utilization to Switch Neuronal Excitability The proapoptotic BH3-only protein BAD can be viewed as a relay: its phosphorylation on Ser 155 switches the preferred source of reducing equivalents for mitochondria from glucose to ketones. Plasma membrane KATP channels are closed in neurons with “glycolytic” mitochondria, as opposed to the ones where mitochondria use ketone bodies and that are less susceptible to seizures. Neuron 2012 74, 600-602DOI: (10.1016/j.neuron.2012.05.003) Copyright © 2012 Elsevier Inc. Terms and Conditions

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