Dysbiosis of bifidobacteria and Clostridium cluster XIVa in the cystic fibrosis fecal microbiota Gwen Duytschaever, Geert Huys, Maarten Bekaert, Linda.

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Dysbiosis of bifidobacteria and Clostridium cluster XIVa in the cystic fibrosis fecal microbiota Gwen Duytschaever, Geert Huys, Maarten Bekaert, Linda Boulanger, Kris De Boeck, Peter Vandamme Journal of Cystic Fibrosis Volume 12, Issue 3, Pages 206-215 (May 2013) DOI: 10.1016/j.jcf.2012.10.003 Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 DGGE fingerprint profiles of the longitudinal study. DGGE fingerprint profiles showing the predominant fecal microbiota of a) family unit 3; b) family unit 6; c) family unit 11; d) family unit 14; e) family unit 16; and f) family unit 18, and discriminating band-classes. Bc: band-class, S1 to 8: sample 1 to 8, CF: patient with CF; SIBLING: healthy sibling. Journal of Cystic Fibrosis 2013 12, 206-215DOI: (10.1016/j.jcf.2012.10.003) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Temporal variation of bifidobacterial abundance. Temporal variation of the genus Bifidobacterium in the five family units displaying one or more potentially discriminating bands assigned to this group. Journal of Cystic Fibrosis 2013 12, 206-215DOI: (10.1016/j.jcf.2012.10.003) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Bifidobacterium and Clostridium cluster XIVa abundance in the cross-sectional study. Graphical representation of bacterial population differences as boxplots. Left: boxplot displaying Bifidobacterium abundance in fecal samples of patients with CF (n=21) and healthy siblings (n=22) from the cross-sectional dataset. The open circle indicates an outlier value. Right: bloxplot displaying Clostridium cluster XIVa abundance in fecal samples of patients with CF (n=21) and healthy siblings (n=22) from the cross-sectional dataset. The p-values are based on the one-tailed paired t-test. Journal of Cystic Fibrosis 2013 12, 206-215DOI: (10.1016/j.jcf.2012.10.003) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 4 Temporal variation of Clostridium cluster XIVa abundance. Temporal variation of members of Clostridium cluster XIVa in the five family units displaying one or more potentially discriminating bands assigned to this group. Journal of Cystic Fibrosis 2013 12, 206-215DOI: (10.1016/j.jcf.2012.10.003) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 5 Clostridium cluster XIVa abundance and weight for height. Scatterplot displaying the correlation between Clostridium cluster XIVa abundance and weight for height (%) (linear mixed model, p=0.03). Journal of Cystic Fibrosis 2013 12, 206-215DOI: (10.1016/j.jcf.2012.10.003) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions