Important modifying factors thought to impact the microbiome throughout life Important modifying factors thought to impact the microbiome throughout life.

Slides:



Advertisements
Similar presentations
Youth violence exposure, adolescent delinquency and anxiety, and the potential mediating role of sleep problems during middle childhood Chelsea M. Weaver.
Advertisements

JAMA Pediatrics Journal Club Slides: Cesarean Delivery, Formula Feeding, and Intestinal Microbiome of Infants Madan JC, Hoen AG, Lundgren SN, et al. Association.
Overexpression of PAI‐1 reverses the arsenite‐mediated effect on senescence Overexpression of PAI‐1 reverses the arsenite‐mediated effect on senescence.
Reduction in immune cell infiltration after stab wound injury in CCR2−/− mice increases proliferation at the injury site Reduction in immune cell infiltration.
Induction of mPer1 mRNA expression by prostaglandin E2 (PGE2) in NIH3T3 cells. Induction of mPer1 mRNA expression by prostaglandin E2 (PGE2) in NIH3T3.
Structures of CK1 inhibitors and their effects on CK1 activity in vitro. Structures of CK1 inhibitors and their effects on CK1 activity in vitro. (A) Structures.
Statistical analysis of transgene expression in pigs generated by lentiviral gene transfer. Statistical analysis of transgene expression in pigs generated.
Morphology of white adipose tissue and muscle in S1/3 KO mice of different ages Morphology of white adipose tissue and muscle in S1/3 KO mice of different.
Juxtavascular astrocytes are enriched in nuclear Aryl hydrocarbon receptor immunostaining at the stab wound injury site in WT mice Juxtavascular astrocytes.
Activation of EphB4 by ephrinB2‐Fc prevents aberrant angiogenesis
Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.
Reduced scar formation in the injured GM of CCR2−/− mice
Colocalization of the human trimethylguanosine synthase 1 and survival of motor neuron proteins. Colocalization of the human trimethylguanosine synthase.
Analysis of the effect of loss of Brca2 on in vivo somatic mutation frequency and mutation type. Analysis of the effect of loss of Brca2 on in vivo somatic.
Lsh does not regulate global histone methylation levels.
Expression of adenylyl cyclases and miR‐142‐3p in CD4+CD25− T cells and CD4+CD25+ regulatory T cells. Expression of adenylyl cyclases and miR‐142‐3p in.
Transcribed strand breaks do not interfere with TFIIIB‐dependent recruitment of pol III to the promoter. Transcribed strand breaks do not interfere with.
The RNA components of eukaryotic RNase P and RNase MRP have multiple common structural features including the P3 domain. The RNA components of eukaryotic.
Protein sequences and three‐dimensional structures of HUB1 (homologous to ubiquitin 1), ubiquitin and ubiquitin‐like modifiers. Protein sequences and three‐dimensional.
Yeast Tgl3p expressed in HeLa cells localizes to lipid droplets.
Yeast containing pICC10 (Tir) and pICC267 (CK18) and pTY474S and pICC267 demonstrated an approximately 12.5‐fold increase in β‐galactosidase activity compared.
SERCA2 is a functional adaptor for the alternative toll‐like receptor 9 (TLR9) signalling in cardiomyocytes Co‐immunoprecipitated TLR9 with SERCA2 antibody.
RNaseB was partially digested with subtilisin, yielding a preparation that contained undigested RNaseB and the faster migrating RNaseBS‐Prot (lane 1).
Measurement of terminal restriction fragments (TRFs) in bone marrow cells from both parents and the G4 progeny. Measurement of terminal restriction fragments.
Location of IL‐17‐producing cell types.
Data analysis of thermal proteome profiling
Characterization and phenotypes of sima mutants.
Cognitive deficits in APPPS1‐21 mice.
Gregory Valentine, MD, Derrick M. Chu, BSc, Christopher J
In vitro modification by SUMO‐1 and SUMO‐2 of HDACs and HDAC‐related proteins. 35S‐labelled in vitro translated HDAC1, HDAC3, HDAC6 and MITR were incubated.
Recognition of double‐stranded telomeric DNA
Identification of SERCA2 as a binding protein of toll‐like receptor 9 (TLR9) Representative image of tandem affinity purification visualized by silver.
Can Your Microbiome Tell You What to Eat?
Direct transcriptional regulation oflncRNAs by HIF AHeat map showing fold regulation by hypoxia and by the indicated HIF siRNA for lncRNAs adjacent to.
Dual role of DRD1 in the dynamic regulation of RNA‐directed DNA methylation. Dual role of DRD1 in the dynamic regulation of RNA‐directed DNA methylation.
VAP‐A is recruited to interorganelle contact sites together with MOSPD2 VAP‐A is recruited to interorganelle contact sites together with MOSPD2 AHeLa cells.
Figure 1 Environmental factors contributing to IBD pathogenesis
Inhibition of ephrinB2/EphB4 signaling does not prevent pericyte recruitment Inhibition of ephrinB2/EphB4 signaling does not prevent pericyte recruitment.
Clinical testing of calcineurin inhibitors cyclosporine A and tacrolimus in autoimmune disorders Clinical testing of calcineurin inhibitors cyclosporine.
Impaired glucose tolerance in adult S1/3 KO mice on a normal chow
The production of reduced or oxidized glutathione can occur at various stages during the formation of native disulphide bonds. The production of reduced.
Distribution of psychrophile genomes and metagenomes in different cold ecosystems(A) Pie chart of the relative proportions of sequenced psychrophile genomes.
Expression of PD‐1 on PBMC and malignant exudate T cells
Rab22A localizes to the E/SE and REs and regulates RE dynamics
FFAT motif‐dependent recruitment of MOSPD2 in ER–endosome contacts by STARD3NL FFAT motif‐dependent recruitment of MOSPD2 in ER–endosome contacts by STARD3NL.
FFAT‐containing proteins recruit the ER‐resident MOSPD2 protein to interorganelle contact sites FFAT‐containing proteins recruit the ER‐resident MOSPD2.
Usp5 sensitivity of S65 ubiquitin mutant chains Structure of ubiquitin in complex with Usp5 (PDB ID: 3IHP). Usp5 sensitivity of S65 ubiquitin mutant chains.
Lack of GTSF1 results in a target RNA (pit‐RNA) unsliced at the cleavage site for MILI‐directed secondary piRNA processing Lack of GTSF1 results in a target.
Lack of GTSF1 causes defects in MILI‐directed piRNA amplification
Example of processed data visualized with “Peak Browser” of ChIP‐Atlas
EphB4 is expressed on endothelium of angiogenic microvessels in murine adult skeletal muscle EphB4 is expressed on endothelium of angiogenic microvessels.
Loss of ANAC032 increases disease susceptibility to Pst DC3000
Diversity of methods utilized to model neurological diseases using patient‐derived iPSCs Diversity of methods utilized to model neurological diseases using.
Lipogenic genes and SREBP1 protein are upregulated in HF‐R
CL1 hydrophobicity determines the specificity for recognition by MARCH6 or TRC8 CL1 hydrophobicity determines the specificity for recognition by MARCH6.
AUP, UBE2G2 and TRC8 facilitate the degradation of mCherry‐CL1 through a shared pathway AUP, UBE2G2 and TRC8 facilitate the degradation of mCherry‐CL1.
Association of total disease burden and disease progression with age‐adjusted blood heteroplasmy Association of total disease burden and disease progression.
Association of total disease burden with age, m
EphB4 stimulation does not cause vessel regression
Figure 2 Lifelong influences on the gut microbiome from
Examples of “Enrichment Analysis”
Structural determinants of Triton specificity
Tummy Time: The Infant Microbiota–IgA Connection
ZBTB48 is required for MTFP1 expression
Target disease and target populations for 21st century vaccine developmentIncluded in the list are the agents of infectious diseases for which vaccines.
Overview of the ChIP‐Atlas data set and computational processing
In vitro interaction studies (related to Fig 2)‏
Loss of the stereocilia and hair bundles in the cochlea of CIB2−/− P120 mice Loss of the stereocilia and hair bundles in the cochlea of CIB2−/− P120 mice.
Miro ELM domains. Miro ELM domains. (A) Top, MiroS shown in the ‘top view’. ELM1 and ELM2 are related by pseudo twofold symmetry, represented by the dyad.
Characterization of GDF11 signalling through type I and type II receptors. Characterization of GDF11 signalling through type I and type II receptors. Gene.
Presentation transcript:

Important modifying factors thought to impact the microbiome throughout life Important modifying factors thought to impact the microbiome throughout life The first contact with microbiota may begin during late gestation, with the largest exposure at the time of delivery. Over time, the abundance and diversity of the infant microbiome increase with life, stabilize around the time that the infant begins to eat solid foods, and persist throughout adulthood. A number of modifying factors are thought to have an influential role in shaping the identity and abundance of the infant microbiota throughout life. However, few studies have specifically examined major modifying factors within childhood and adolescence. Kjersti Aagaard et al. EMBO Rep. 2016;embr.201643483 © as stated in the article, figure or figure legend