Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training S.G. Petersen, T. Saxne, D. Heinegard,

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Presentation transcript:

Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training S.G. Petersen, T. Saxne, D. Heinegard, M. Hansen, L. Holm, S. Koskinen, C. Stordal, H. Christensen, P. Aagaard, M. Kjaer Osteoarthritis and Cartilage Volume 18, Issue 1, Pages 34-40 (January 2010) DOI: 10.1016/j.joca.2009.07.004 Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Time-schedule. Osteoarthritis and Cartilage 2010 18, 34-40DOI: (10.1016/j.joca.2009.07.004) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Progress of participants throughout the trial. Osteoarthritis and Cartilage 2010 18, 34-40DOI: (10.1016/j.joca.2009.07.004) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Leg-press 5 RM tests. All groups increased significantly in strength (***P≤0.001). Osteoarthritis and Cartilage 2010 18, 34-40DOI: (10.1016/j.joca.2009.07.004) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Knee extension 5 RM tests. All groups increased significantly in strength (**P≤0.01, ***P≤0.001). Osteoarthritis and Cartilage 2010 18, 34-40DOI: (10.1016/j.joca.2009.07.004) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Levels of serum COMP (on a logarithmic scale) pre and post 12-week of strength training. Each line represents an individual patient. We observed a statistical significant decrease in serum COMP levels in the glucosamine-group (P=0.012). Osteoarthritis and Cartilage 2010 18, 34-40DOI: (10.1016/j.joca.2009.07.004) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Urine CTX-II levels (on a logarithmic scale) pre and post 12-weeks strength training. Each line represents an individual patient. No significant alterations in CTX levels were observed in any of the groups. Osteoarthritis and Cartilage 2010 18, 34-40DOI: (10.1016/j.joca.2009.07.004) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions