Sara J. Brown, MRCP, Caroline L

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Presentation transcript:

Filaggrin null mutations and childhood atopic eczema: A population-based case-control study Sara J. Brown, MRCP, Caroline L. Relton, PhD, Haihui Liao, MD, Yiwei Zhao, MD, Aileen Sandilands, PhD, Ian J. Wilson, PhD, John Burn, MD, Nick J. Reynolds, MD, W. H. Irwin McLean, PhD, DSc, Heather J. Cordell, DPhil Journal of Allergy and Clinical Immunology Volume 121, Issue 4, Pages 940-946.e3 (April 2008) DOI: 10.1016/j.jaci.2008.01.013 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow diagram showing recruitment of children to the study. Journal of Allergy and Clinical Immunology 2008 121, 940-946.e3DOI: (10.1016/j.jaci.2008.01.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Logistic regression analysis to estimate odds of disease (atopic eczema) with FLG null mutations comparing genotype- and allele-based models. The 95% CIs are as follows: genotypic model heterozygotes versus wild type, 0.7 to 1.9; homozygote mutants versus wild type, 3.3 to 217.1; allelic model, 1.2 to 8.6. The likelihood ratio test, to test whether the allelic model can be nested in full within the genotypic model of disease, shows that the genotypic model fits the data significantly better (P = 1.8 × 10−3). Journal of Allergy and Clinical Immunology 2008 121, 940-946.e3DOI: (10.1016/j.jaci.2008.01.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Questionnaire used in this study. Journal of Allergy and Clinical Immunology 2008 121, 940-946.e3DOI: (10.1016/j.jaci.2008.01.013) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions