Antti E. Seppo, PhD, Chloe A. Autran, MSc, Lars Bode, PhD, Kirsi M

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Presentation transcript:

Human milk oligosaccharides and development of cow's milk allergy in infants Antti E. Seppo, PhD, Chloe A. Autran, MSc, Lars Bode, PhD, Kirsi M. Järvinen, MD, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 2, Pages 708-711.e5 (February 2017) DOI: 10.1016/j.jaci.2016.08.031 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Human milk oligosaccharide levels in mothers who have an infant with CMA and in those with a child without CMA. Nonparametric P values (Wilcoxon) for the difference in distribution between CMA and non-CMA samples are indicated in each panel. For HMO abbreviations, see Table E2. Journal of Allergy and Clinical Immunology 2017 139, 708-711.e5DOI: (10.1016/j.jaci.2016.08.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A correlation heatmap and cluster dendrogram for expression of HMOs. AU (approximately unbiased) P value for each cluster is shown in the dendrogram. Significant clusters (AU > 95) are labeled (a, b, and c). Heatmap of the distance matrix is shown with Spearman correlation values on the lower triangle and the corresponding P value in the upper triangle. P values are indicated as follows: ****≤.001, ***≤.01, **≤.05, *≤.1. For HMO abbreviations, see Table E2. Journal of Allergy and Clinical Immunology 2017 139, 708-711.e5DOI: (10.1016/j.jaci.2016.08.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Human milk oligosaccharide levels in milk as a function of baby's age (duration of lactation). A univariate model was fitted to estimate the correlation for each HMO. The r2 and corresponding P values are indicated on the basis of the regression model for each HMO. Journal of Allergy and Clinical Immunology 2017 139, 708-711.e5DOI: (10.1016/j.jaci.2016.08.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Human milk oligosaccharide levels in mothers who have an infant with CMA with an immediate-type reaction (immediate), a delayed, non–IgE-mediated reaction (delayed), and in those with an infant without CMA (no). In the box plots, the median is represented by a horizontal line within the box indicating the 25th to 75th percentile and the whiskers show the 5th to 95th percentile. Samples from FUT2 secretors are shown in blue, whereas samples from nonsecretors are shown in red. Nonparametric P values (Kruskal-Wallis) for the difference in distribution between immediate, delayed, and no CMA samples (pKW) and nonparametric (Wilcoxon) P values for the difference between immediate and delayed CMA samples (pW) are indicated in each panel. P values were corrected for multiple testing using the Benjamini-Hochberg method. For HMO abbreviations, see Table E2. Journal of Allergy and Clinical Immunology 2017 139, 708-711.e5DOI: (10.1016/j.jaci.2016.08.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions