Thoughts on Obesity and Brain Glucose

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Thoughts on Obesity and Brain Glucose Michael T. Heneka, Pierluigi Nicotera Cell Volume 165, Issue 4, Pages 773-775 (May 2016) DOI: 10.1016/j.cell.2016.04.057 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 High-Fat Diet Stimulates a Brain-Driven Homeostatic Response (A) VEGF restores activity of the glucose transporter Glut-1, previously downregulated by the high-fat diet (HFD) (most likely by saturated fatty acids [SFA]). (B) The homeostatic restoration of brain glucose uptake is abolished if macrophages are VEGF deficient. (C) VEGF deficiency exacerbates cognitive defects in mouse models of Amyloid β deposition (APP/PS1). Cell 2016 165, 773-775DOI: (10.1016/j.cell.2016.04.057) Copyright © 2016 Elsevier Inc. Terms and Conditions