Dose-dependent effects of capsaicin nasal challenge: In vivo evidence of human airway neurogenic inflammation Alvin M. Sanico, MDa, Satsuki Atsuta, MDa,

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Presentation transcript:

Dose-dependent effects of capsaicin nasal challenge: In vivo evidence of human airway neurogenic inflammation Alvin M. Sanico, MDa, Satsuki Atsuta, MDa, David Proud, PhDa, Alkis Togiaas, MDa,b Journal of Allergy and Clinical Immunology Volume 100, Issue 5, Pages 632-641 (November 1997) DOI: 10.1016/S0091-6749(97)70167-2 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Design of study. Subjects underwent nasal spray challenges with 1 μg, 10 μg, and 100 μg of capsaicin, given 1 week apart in a double-blind, randomized, crossover manner. Nasal lavage samples collected before and after challenge were analyzed for leukocyte counts, as well as for albumin and lysozyme levels. Journal of Allergy and Clinical Immunology 1997 100, 632-641DOI: (10.1016/S0091-6749(97)70167-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Changes in symptom scores for burning from pre- to postchallenge with 1 μg, 10 μg, and 100 μg of capsaicin. Data are shown with modified box plots. Heavy marks within bars represent median values; top and bottom of bars represent 75th and 25th percentiles, respectively. Comparison of pre- and postchallenge symptom scores by Wilcoxon paired test showed significant increases (*p < 0.05) in burning sensation at various time points after capsaicin administration. Comparison of Δ symptom scores within the three capsaicin doses by Friedman's ANOVA demonstrated significant differences at various time points as shown, suggesting that symptoms induced by capsaicin are mostly dose-dependent. Journal of Allergy and Clinical Immunology 1997 100, 632-641DOI: (10.1016/S0091-6749(97)70167-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Changes in symptom scores for congestion from pre- to postchallenge with 1 μg, 10 μg, and 100 μg of capsaicin. Data are shown with modified box plots. Comparison of pre- and postchallenge symptom scores by Wilcoxon paired test showed significant increases (*p < 0.05) in nasal congestion at various time points after capsaicin administration. Comparison of Δ symptom scores within the three capsaicin doses by Friedman's ANOVA demonstrated significant differences at various time points as shown, suggesting that symptoms induced by capsaicin are mostly dose-dependent. Journal of Allergy and Clinical Immunology 1997 100, 632-641DOI: (10.1016/S0091-6749(97)70167-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Changes in symptom scores for rhinorrhea from pre- to postchallenge with 1 μg, 10 μg, and 100 μg of capsaicin. Data are shown with modified box plots. Comparison of pre- and postchallenge symptom scores by Wilcoxon paired test showed significant increases (*p < 0.05) in rhinorrhea at various time points after capsaicin administration. Comparison of Δ symptom scores within the three capsaicin doses by Friedman's ANOVA demonstrated significant differences at various time points as shown, suggesting that symptoms induced by capsaicin are mostly dose-dependent. Journal of Allergy and Clinical Immunology 1997 100, 632-641DOI: (10.1016/S0091-6749(97)70167-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Changes in leukocyte counts from before to after challenge with 1μg, 10 μg, and 100 μg of capsaicin. Comparison of pre- and postchallenge leukocyte counts by Wilcoxon paired test showed significant increases (*p < 0.05) 1 hour and 4 hours after 10 μg of capsaicin. There was no significant leukocyte increase after 1 μg of capsaicin. Comparison of change in leukocytes within the three capsaicin doses by Friedman's ANOVA indicated a trend toward greater leukocyte influx with increasing capsaicin doses, which plateaus at the 4-hour time point. Caps, Capsaicin. Journal of Allergy and Clinical Immunology 1997 100, 632-641DOI: (10.1016/S0091-6749(97)70167-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Changes in albumin levels from before to after challenge with 1 μg, 10 μg, and 100 μg of capsaicin. Comparison of pre- and postchallenge albumin levels by Wilcoxon paired test showed significant increases (*p < 0.05) after 10 μg and 100 μg of capsaicin at the 30-minute time point. There was no significant albumin increase after 1 μg of capsaicin at any time point. Comparison of Δ albumin within the three capsaicin doses by Friedman's ANOVA indicated that acute albumin leakage is dose-dependent (p = 0.0007 at 30 minutes). Caps, Capsaicin. Journal of Allergy and Clinical Immunology 1997 100, 632-641DOI: (10.1016/S0091-6749(97)70167-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 7 Changes in lysozyme levels from before to after challenge with 1 μg, 10 μg, and 100 μg of capsaicin. Comparison of pre- and postchallenge lysozyme levels by Wilcoxon paired test showed significant increases (*p < 0.05) after 10 μg and 100 μg of capsaicin at the 30-minute time point. There was no significant increase in lysozyme after 1 μg of capsaicin at any time point. Comparison of Δ lysozyme within the three capsaicin doses by Friedman's ANOVA indicated that acute increase in this glandular product is dose-dependent (p = 0.001 at 30 minutes). Caps, Capsaicin. Journal of Allergy and Clinical Immunology 1997 100, 632-641DOI: (10.1016/S0091-6749(97)70167-2) Copyright © 1997 Mosby, Inc. Terms and Conditions