Volume 130, Issue 4, Pages (April 2006)

Slides:



Advertisements
Similar presentations
Early Administration of Azathioprine Versus Conventional Management of Crohn’s Disease : A Randomized Controlled Trial F1. Ja Won Koo JACQUES COSNES, ANNE.
Advertisements

Incidence of Autoimmune Diseases in Celiac Disease: Protective Effect of the Gluten- Free Diet Jacques Cosnes, Christophe Cellier, Sheila Viola, Jean–Frederic.
Overview and pathogenesis of celiac disease Martin F. Kagnoff Gastroenterology Volume 128, Issue 4, Pages S10-S18 (April 2005) DOI: /j.gastro
Prognostic factors in patients with Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1 Guillaume Cadiot, Albert Vuagnat, Isabelle Doukhan,
Volume 136, Issue 3, Pages (March 2009)
Volume 126, Issue 1, Pages (January 2004)
Ashwin N. Ananthakrishnan, Millie D. Long, Christopher F
Volume 145, Issue 4, Pages e2 (October 2013)
Noncardiac Chest Pain Clinical Gastroenterology and Hepatology
Certolizumab Pegol in Patients With Moderate to Severe Crohn's Disease and Secondary Failure to Infliximab  William J. Sandborn, Maria T. Abreu, Geert.
Nitsan Maharshak, Scott E. Plevy 
Volume 135, Issue 4, Pages (October 2008)
Christoph Lübbert, Babett Holler  Gastroenterology 
Severe Skin Lesions Cause Patients With Inflammatory Bowel Disease to Discontinue Anti–Tumor Necrosis Factor Therapy  Jean–François Rahier, Sébastien.
Incidence and importance of antibody responses to infliximab after maintenance or episodic treatment in Crohn’s disease  Stephen B Hanauer, Carrie L Wagner,
Ira J. Fox, Stephen C. Strom  Gastroenterology 
Volume 154, Issue 1, Pages e6 (January 2018)
Subcutaneous Ustekinumab Provides Clinical Benefit for Two-Thirds of Patients With Crohn’s Disease Refractory to Anti–Tumor Necrosis Factor Agents  Pauline.
The Functional Gastrointestinal Disorders and the Rome III Process
Volume 136, Issue 3, Pages (March 2009)
Volume 129, Issue 6, Pages (December 2005)
Risks and Benefits of Infliximab for the Treatment of Crohn’s Disease
Clinical Challenges and Images in GI
Volume 155, Issue 4, Pages (October 2018)
Volume 115, Issue 1, Pages (July 1998)
A Historical Perspective on Clinical Advances in Pancreatic Diseases
Volume 150, Issue 4, Pages (April 2016)
Gary R. Lichtenstein, Brian G. Feagan, Russell D. Cohen, Bruce A
Association of Trough Serum Infliximab to Clinical Outcome After Scheduled Maintenance Treatment for Crohn’s Disease  Elana A. Maser, Renata Villela,
Interferon-β-1a for the Treatment of Steroid-Refractory Ulcerative Colitis: A Randomized, Double-Blind, Placebo-Controlled Trial  Eugen Musch, Tilo Andus,
Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection
AGA Clinical Practice Update on Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: Expert Review  Jean-Frederic Colombel,
David J. Hass, Colleen M. Brensinger, James D. Lewis, Gary R
Severe Constipation Clinical Gastroenterology and Hepatology
Ronnie Fass, Stephen J. Sontag, Barry Traxler, Mark Sostek 
Volume 132, Issue 5, Pages (May 2007)
Saccharomyces boulardii Does Not Prevent Relapse of Crohn's Disease
Volume 145, Issue 5, Pages e5 (November 2013)
Volume 142, Issue 1, Pages e5 (January 2012)
Volume 132, Issue 1, Pages (January 2007)
David H. Bruining, William J. Sandborn 
Volume 130, Issue 3, Pages (March 2006)
Volume 135, Issue 5, Pages (November 2008)
Volume 133, Issue 2, Pages (August 2007)
Ashwin N. Ananthakrishnan, David Lieberman  Gastroenterology 
Inflammatory bowel disease in spouses and their offspring
Antoine Debourdeau, Anne Bozon, Romain Altwegg  Gastroenterology 
Volume 116, Issue 2, Pages (February 1999)
Volume 150, Issue 5, Pages (May 2016)
Long-term Outcome of Perianal Fistulizing Crohn's Disease Treated With Infliximab  Guillaume Bouguen, Laurent Siproudhis, Emmanuel Gizard, Timothée Wallenhorst,
Volume 150, Issue 2, Pages e4 (February 2016)
Volume 149, Issue 6, Pages (November 2015)
Volume 150, Issue 7, Pages (June 2016)
Multiple Unusual Ulcerated Skin Lesions in a Crohn's Disease Patient
Safety of Long-term Treatment With Certolizumab Pegol in Patients With Crohn's Disease, Based on a Pooled Analysis of Data From Clinical Trials  Edward.
Volume 126, Issue 2, Pages (February 2004)
Chronic Diarrhea Clinical Gastroenterology and Hepatology
Secondary Prophylaxis of Hepatic Encephalopathy: An Open-Label Randomized Controlled Trial of Lactulose Versus Placebo  Barjesh Chander Sharma, Praveen.
Volume 151, Issue 4, Pages (October 2016)
Volume 126, Issue 1, Pages (January 2004)
Walter Reinisch, Jean-Frederic Colombel, William J
Volume 117, Issue 3, Pages (September 1999)
Changing of the Guards: 2011–2016 Gastroenterology Team
Volume 128, Issue 7, Pages (June 2005)
Michelle Maria Pietzak  Gastroenterology 
Issue Highlights Clinical Gastroenterology and Hepatology
Volume 128, Issue 4, Pages (April 2005)
Medical Therapy for Refractory Pediatric Crohn’s Disease
Volume 121, Issue 2, Pages (August 2001)
Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis  Jean-Frédéric Colombel,
Presentation transcript:

Volume 130, Issue 4, Pages 1054-1061 (April 2006) Infliximab Plus Azathioprine for Steroid-Dependent Crohn’s Disease Patients: A Randomized Placebo-Controlled Trial  Marc LÉmann, Jean–Yves Mary, Bernard Duclos, Michel Veyrac, Jean–Louis Dupas, Jean Charles Delchier, David Laharie, Jacques Moreau, Guillaume Cadiot, Laurence Picon, Arnaud Bourreille, Iradj Sobahni, Jean–Frederic Colombel  Gastroenterology  Volume 130, Issue 4, Pages 1054-1061 (April 2006) DOI: 10.1053/j.gastro.2006.02.014 Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 1 Flow chart of patients randomized in the trial. The figures in parentheses correspond to the number of patients in the naive stratum and the failure stratum, respectively. Gastroenterology 2006 130, 1054-1061DOI: (10.1053/j.gastro.2006.02.014) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 2 Percent of patients in clinical remission and off steroids at weeks 12, 24 (primary end point), and 52 (follow-up evaluation). The figures below the bars correspond to the number of patients analyzed at each date. □, AZA/6-MP + placebo; ■, AZA/6-MP + infliximab 5 mg/kg. Gastroenterology 2006 130, 1054-1061DOI: (10.1053/j.gastro.2006.02.014) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 3 Percent of patients in clinical remission and off steroids in the 2 strata at weeks 12, 24 (primary end point), and 52 (follow-up evaluation). The figures below the bars correspond to the number of patients analyzed at each date. □, AZA/6-MP + placebo; ■, AZA/6-MP + infliximab 5 mg/kg. Gastroenterology 2006 130, 1054-1061DOI: (10.1053/j.gastro.2006.02.014) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions