Direct Binding and Activation of Receptor Tyrosine Kinases by Collagen

Slides:



Advertisements
Similar presentations
CELL COMMUNICATION. YOU MUST KNOW… THE 3 STAGES OF CELL COMMUNICATION: RECEPTION, TRANSDUCTION, AND RESPONSE HOW G-PROTEIN-COUPLED RECEPTORS RECEIVE CELL.
Advertisements

Extracellular Matrix of the Animal Cell. What is the extracellular matrix (ECM)? Something that is made by virtually all multi-cellular organisms. Elaborate.
The Extracellular Matrix Michael Malahy. ECM in Epithelial Sheets 3 types of molecules abundant in ECM Proteoglycans Cushion cells and bind extracellular.
Signal Pathways in Eukaryotic Cells Overview. Lipid Soluble Hormones.
Michael Jeltsch Tyrosine kinases
BIOL 5190/6190 Cellular & Molecular Singal Transduction
3.3 Cell Membrane KEY CONCEPT The cell membrane is a barrier that separates a cell from the external environment.
Signal Transduction I Receptors & Ligands. Signal Transduction.
Signaling Machinery The Signals The Receivers
Chapter 6 Section 6.7. Vocabulary You Need To Know Cell wall Primary Cell Wall Middle Lamella Secondary Cell Wall ECM(Extracellular matrix) Collagen Proteoglycans.
Cell Communication Chapter 9.
Chapter 11 Cell Communication. Local signaling: Paracrine Synaptic Long distance signaling: Hormonal. Chapter 11 Cell Communication.
Cell Communication Chapter 9. 2 Cell Communication Communication between cells requires: ligand: the signaling molecule receptor protein: the molecule.
Negative regulation of cell cycle by intracellular signals Checkpoint p53 detects DNA damage & activates p21 p21 inhibits cdk2-cyclinA Intracellular Regulation.
Date of download: 9/17/2016 Copyright © 2016 McGraw-Hill Education. All rights reserved. Schematic comparison of structural features of cell surface growth.
Schematic comparison of structural features of cell surface growth factor receptor tyrosine kinases and membrane-associated tyrosine kinase oncogene products.
3.D.3 Signal Transduction Signal transduction pathways link signal reception with cellular response.
Chapter 11 – Cell Communication
Inducing Angiogenesis
Eph-Ephrin Bidirectional Signaling in Physiology and Disease
Ambiguous Origin: Two Sides of an Ephrin Receptor Tyrosine Kinase
Volume 100, Issue 1, Pages (January 2000)
Heparin-Induced Cancer Cell Death
Signaling Machinery The Signals The Receivers
Nat. Rev. Endocrinol. doi: /nrendo
Cell to Cell Communication via Enzyme Linked Receptors
Cell Communication Chapter 6.
Volume 5, Issue 6, Pages (June 2009)
دکتر مجیری داروساز متخصص فارماکولوژی
Kindlins Current Biology
Cell Signaling by Receptor Tyrosine Kinases
Integrins and Mutant p53 on the Road to Metastasis
Seppo Vainio, Ulrich Müller  Cell 
Integrins and Mutant p53 on the Road to Metastasis
An Uncommon Tail about the Common γ-Chain
Platelet-derived growth factor receptors (PDGFRs) and ligand patterns.
Epigenetics Drives RAGs to Recombination Riches
Jo-Ellen Murphy, Caroline Robert, Thomas S. Kupper 
FGFR Signaling as a Target for Lung Cancer Therapy
Pattern Recognition Receptors
G Protein Signaling and Asymmetric Cell Division
Eph Nomenclature Committee  Cell 
Cell Communication CHAPTER 11.
Volume 12, Issue 3, Pages (September 2003)
Vascular frontiers without borders
Steroid hormones: Interactions with membrane-bound receptors
Cell membranes are composed of ___ ____________ ______.
Hip1 and Hippi Participate in a Novel Cell Death-Signaling Pathway
Signaling Network Model of Chromatin
Shifted from Wnt to Hedgehog Signaling Pathways
Death receptor-mediated apoptosis and the liver
Tetherin Is as Tetherin Does
Exploring the Neighborhood
The suppressors of cytokine signaling (SOCS) proteins
Masaru Katoh  Journal of Investigative Dermatology 
Fibronectin at Select Sites Binds Multiple Growth Factors and Enhances their Activity: Expansion of the Collaborative ECM-GF Paradigm  Jia Zhu, Richard.
11.2 Cell Communication.
Volume 84, Issue 3, Pages (February 1996)
Insider Influence on ErbB Activity
Irina Dudanova, Rüdiger Klein  Neuron 
Intercellular Networks Underlying Developmental Decisions
GPC5 Gene and Its Related Pathways in Lung Cancer
Volume 1, Issue 3, Pages (April 2002)
Novel aspects of complement in kidney injury
cGAS Dimerization Entangles DNA Recognition
Cell Signaling by Receptor Tyrosine Kinases
Neha Vaid, Anca Macovei, Narendra Tuteja  Molecular Plant 
Volume 12, Issue 6, Pages (December 2007)
Vascular frontiers without borders
Melanocytes: A Window into the Nervous System
Presentation transcript:

Direct Binding and Activation of Receptor Tyrosine Kinases by Collagen Joseph Schlessinger  Cell  Volume 91, Issue 7, Pages 869-872 (December 1997) DOI: 10.1016/S0092-8674(00)80477-8

Figure 1 Different Paradigms for Ligand-Induced Activation of Receptor Tyrosine Kinases (I) A soluble PDGF dimer cross-links two PDGF receptors (PDGFR) leading to activation of the cytoplasmic tyrosine kinase domain. (II) FGF binds to FGF receptors (FGFR) monovalently. Oligomerization of FGF molecules by means of multimeric interactions with membrane-attached heparin sulfate proteoglycan receptor (HSPR) induces FGFR dimerization and tyrosine kinase activation. (III) Transmembrane (TM) Ephrins (also GPI-linked Ephrins) expressed on the cell surface of a cell bind to EPH receptors (EphR) expressed on the cell surface of neighboring cells. Binding is followed by receptor dimerization and protein tyrosine kinase activation. (IV) GDNF induces dimerization of the GPI-linked GDNF receptor (GDNFR). Ligand-occupied GDNFRs form a complex with the receptor tyrosine kinase Ret. GDNF-induced dimerization of GDNFR/Ret complex leads to protein tyrosine kinase activation. (V) Both soluble or surface-attached collagen fibers bind to DDR1 and DDR2 leading to tyrosine kinase activation. Integrities of the Gly-X-Y repeat and carbohydrates attached to collagen are essential for DDR receptor activation. Cell 1997 91, 869-872DOI: (10.1016/S0092-8674(00)80477-8)

Figure 2 A Scheme Describing Activation of Receptor Tyrosine Kinases DDR1 or DDR2 by Either Soluble or Surface-Bound Collagen Fibers The signal generated by activation of DDR receptors acts in concert with the signal generated by binding of collagen to classical α2β1 and α1β1 integrins (Clark and Brugge 1995). Cell 1997 91, 869-872DOI: (10.1016/S0092-8674(00)80477-8)