The Microbiome of the Prostate Tumor Microenvironment

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Presentation transcript:

The Microbiome of the Prostate Tumor Microenvironment Ilaria Cavarretta, Roberto Ferrarese, Walter Cazzaniga, Diego Saita, Roberta Lucianò, Elisa R. Ceresola, Irene Locatelli, Laura Visconti, Giovanni Lavorgna, Alberto Briganti, Manuela Nebuloni, Claudio Doglioni, Massimo Clementi, Francesco Montorsi, Filippo Canducci, Andrea Salonia European Urology Volume 72, Issue 4, Pages 625-631 (October 2017) DOI: 10.1016/j.eururo.2017.03.029 Copyright © 2017 European Association of Urology Terms and Conditions

Fig. 1 Bacterial average relative abundance in prostate tumor (T), peri-tumor (PT), and nontumor (NT) samples. Average distribution of major taxa is represented by bar graphs (A) phylum, (B) class, (C) order, (D) family, (E) genus. European Urology 2017 72, 625-631DOI: (10.1016/j.eururo.2017.03.029) Copyright © 2017 European Association of Urology Terms and Conditions

Fig. 2 Beta diversity analysis. Principal component (PC) analysis plot of weighted UniFrac metrics for tumor (yellow dots), peri-tumor (blue dots), and nontumor (red dots) areas of prostate samples. Multivariate analysis shows that the microbiome of the prostate is similar among the patients and that the samples from the three prostate areas do not cluster by their overall microbiome composition. However, for some patients, nontumoral areas appear distant from the tumor and peri-tumor samples. European Urology 2017 72, 625-631DOI: (10.1016/j.eururo.2017.03.029) Copyright © 2017 European Association of Urology Terms and Conditions