A Flt3L Encounter: mTOR Signaling in Dendritic Cells Li Wu  Immunity  Volume 33, Issue 4, Pages 580-582 (October 2010) DOI: 10.1016/j.immuni.2010.10.001 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 mTOR Mediates Flt3L Signaling in Dendritic Cell Development and Homeostasis Binding of Flt3L to its receptor expressed on the surface of DC precursors or DC induces activation of its downstream PI3K-Akt-mTOR signaling pathway that leads to DC differentiation and expansion. The PI3K-Akt-mTOR pathway can be suppressed by Pten, a key inhibitor of Akt signaling, and by rapamycin, the specific inhibitor of mTOR, which leads to restrained DC development and expansion. Flt3L signaling may directly activate Stat3 pathway and lead to DC development. Immunity 2010 33, 580-582DOI: (10.1016/j.immuni.2010.10.001) Copyright © 2010 Elsevier Inc. Terms and Conditions