Proposal: Total Synthesis of Biyouyanagin A Isabelle Bonnaventure, Maude Poirier, Jean-Nicolas Desrosiers, Sébastien Goudreau, Alexandre Côté March 20th, 2007
Retrosynthesis
Hyperolactone C: Chirality Installation
Hyperolactone C: O-H Insertion Entry R Yield (%) 1 Me 86 2 Et 92 3 Bn 91
Hyperolactone C: Carroll Rearrangement
Hyperolactone C: Formation of the Spirolactone Unit
Zingiberene: Chirality Installation
Zingiberene: Cyclization
The [2+2] Approach
When the Steric Hindrance is Increased
Summary