Pathology Analysis Reveals That Dysplastic Pancreatic Ductal Lesions Are Frequent in Patients With Hereditary Pancreatitis  Vinciane Rebours, Philippe Lévy, Jean–François Mosnier, Jean–Yves Scoazec, Marie–Sophie Soubeyrand, Jean–François Fléjou, Bruno Turlin, Pascal Hammel, Philippe Ruszniewski, Pierre Bedossa, Anne Couvelard  Clinical Gastroenterology and Hepatology  Volume 8, Issue 2, Pages 206-212 (February 2010) DOI: 10.1016/j.cgh.2009.09.009 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Histologic and immunohistochemical aspects of PanIN lesions. (A) PanIN-2 and (B) PanIN-3 coexisting in the same specimen. The ducts are less than 5 mm in diameter. PanIN-2 consisted of epithelial lesions (arrows) with moderate dysplasia. The nuclei had some abnormalities such as nuclear crowding, enlarged nuclei, pseudostratification, and hyperchromatism. PanIN-3 lesions consist of a papillary epithelium with severe dysplasia. The cells present severe atypias with irregular nuclei and loss of nuclear polarity. (C and D) Immunohistochemical expression of MIB-1 (Ki-67) and p53 in PanIN-3 lesions. (C) MIB-1 and (D) p53 are expressed by 50% and 30% of epithelial cells, respectively. (E and F) PanIN lesions (arrows) are present in the pancreatic specimen either (E) within large amounts of fibrosis or (F) at contact with more preserved pancreatic lobules. f, fibrosis; l, pancreatic lobules. Clinical Gastroenterology and Hepatology 2010 8, 206-212DOI: (10.1016/j.cgh.2009.09.009) Copyright © 2010 AGA Institute Terms and Conditions