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Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2016.58 Figure 4 Management of immune-related adverse events excluding skin and endocrine toxicities Figure 4 | Management of immune-related adverse events excluding skin and endocrine toxicities. General guidelines for the management of immune-related adverse events attributed to checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) or programmed cell death 1 (PD-1). Boutros, C. et al. (2016) Safety profiles of anti-CTLA‑4 and anti‑PD‑1 antibodies alone and in combination Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2016.58