New Lamp Posts Allow for New Views of the Immunological Synapse

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New Lamp Posts Allow for New Views of the Immunological Synapse Saravanan Raju, Andrey S. Shaw Immunity Volume 42, Issue 5, Pages 781-783 (May 2015) DOI: 10.1016/j.immuni.2015.05.008 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Coordinated Steps in Synapse Formation and Cytolytic Granule Release The motile lymphocyte is polarized with the uropod-MTOC in the rear and an actin-rich lamellipodial leading edge. It uses the actin-rich leading edge to make contact with the target cell or APC. Within 1 min after contact with the target, the cSMAC forms, and this is correlated with actin clearing, granule movement to the centrosome, and centrosome movement to the synapse. Within 2–5 min, the centrosome and associated granules are in a position between the nucleus and the target cell. Granule release occurs with movement of the centrosome to the plasma membrane. Immunity 2015 42, 781-783DOI: (10.1016/j.immuni.2015.05.008) Copyright © 2015 Elsevier Inc. Terms and Conditions