P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

Slides:

Advertisements

Similar presentations

Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.

Advertisements

The association between metacarpal ratio, radiographic hand and knee osteoarthritis and its progression after meniscectomy P.T. Paradowski, L.S. Lohmander,

Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling W. Madej, A. van Caam, E.N. Blaney Davidson, P.M.

The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1 A. van Caam, E. Blaney Davidson, A.

Mesenchymal stromal cells for cartilage repair in osteoarthritis

The epidemiology and impact of pain in osteoarthritis

P.-S. Hsu, H.-H. Lin, C.-R. Li, W.-S. Chung

Osteoarthritis as a disease of mechanics

Bone Morphogenetic Proteins and articular cartilage

Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors A. van Caam, W. Madej, E. Thijssen, A.

No evidence for the effectiveness of a multidisciplinary group based treatment program in patients with osteoarthritis of hands on the short term; results.

Unloading results in rapid loss of TGFβ signaling in articular cartilage: role of loading- induced TGFβ signaling in maintenance of articular chondrocyte.

Osteoarthritis year in review 2016: biology

Avoidance of activity and limitations in activities in patients with osteoarthritis of the hip or knee: a 5 year follow-up study on the mediating role.

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

The course of ultrasonographic abnormalities in knee osteoarthritis: 1 year follow up K. Bevers, J.W.J. Bijlsma, J.E. Vriezekolk, C.H.M. van den Ende,

Osteoarthritis and Cartilage

Efficacy and safety of intraarticular hyaluronic acid in the treatment of hip osteoarthritis: a systematic review J.C. Fernández López, M.D., Ph.D.,

The effect of waiting time on health and quality of life outcomes and costs of medication in hip replacement patients: a randomized clinical trial U.

Time to be positive about negative data?

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

The S100A9 inhibitor paquinimod (ABR ) reduces synovial activation, osteophyte formation and cartilage damage in experimental osteoarthritis R.F.

J. Avouac, M.D., L. Gossec, M.D., M. Dougados, M.D.

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5- Smad2/3 pathway. Potential role in OA related pain? E.N. Blaney.

Stem cell therapy for human cartilage defects: a systematic review

S. Sonne-Holm, M.D., Dr. Sci., S. Jacobsen, M.D.

Risk factors associated with reduced work productivity among people with chronic knee pain M. Agaliotis, M. Fransen, L. Bridgett, L. Nairn, M. Votrubec,

J. Ranstam Osteoarthritis and Cartilage

Effectiveness of thermal and athermal short-wave diathermy for the management of knee osteoarthritis: a systematic review and meta-analysis Y. Laufer,

The course of limitations in activities over 5 years in patients with knee and hip osteoarthritis with moderate functional limitations: risk factors for.

Osteoarthritis and Cartilage

Utilization rates of hip arthroplasty in OECD countries

Scientific production and impact of national registers: the example of orthopaedic national registers P. Boyer, I. Boutron, P. Ravaud Osteoarthritis.

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis M. Blagojevic, C. Jinks, A. Jeffery, K.P.

A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading H.E. Kloefkorn, B.Y. Jacobs,

T. J. Hoogeboom, C. H. M. van den Ende, G. van der Sluis, J. Elings, J

Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing.

Who should have a joint replacement? A plea for more ‘phronesis’

Cartilage adaptation after anterior cruciate ligament injury and reconstruction: implications for clinical management and research? A systematic review.

Osteoarthritis and Cartilage

Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: a systematic literature review C.M.M. Peeters, M.J.C. Leijs, M. Reijman,

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression D.F.G. Remst,

Bone Morphogenetic Proteins and articular cartilage

Gene expression analysis of OA synovium reveals elevation of TGF-ß responsive genes in OA-related fibrosis D.F. Remst, A.B. Blom, E.N. Blaney Davidson,

F. Dell'Accio Osteoarthritis and Cartilage

I.C. Olsen, T.K. Kvien, T. Uhlig Osteoarthritis and Cartilage

N. Takahashi, Ph. D. , K. Rieneck, M. D. , P. M. van der Kraan, Ph. D

Osteoarthritis and Cartilage

D.J. Hunter Osteoarthritis and Cartilage

Pain trajectory groups in persons with, or at high risk of, knee osteoarthritis: findings from the Knee Clinical Assessment Study and the Osteoarthritis.

S.G. Muthuri, D.F. McWilliams, M. Doherty, W. Zhang

Confirmation of two major polyarticular osteoarthritis (POA) phenotypes – differentiation on the basis of joint topography G.J. Carroll, W.H. Breidahl,

Limited effects of exercises in people with hand osteoarthritis: results from a randomized controlled trial N. Østerås, K.B. Hagen, M. Grotle, A.-L.

Instruments to assess physical activity in patients with osteoarthritis of the hip or knee: a systematic review of measurement properties C.B. Terwee,

R. H. J. Das, M. Sc. , H. Jahr, Ph. D. , J. A. N. Verhaar, M. D. , Ph

C. Ratzlaff, M. Koehoorn, J. Cibere, J. Kopec

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

WNT and WISP1 expression in the synovium induces production of cartilage-degrading metalloproteinases by synovial cells M.H. van den Bosch, A.B. Blom,

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

N. Frey, T. Hügle, S.S. Jick, C.R. Meier, J. Spoendlin

Osteoarthritis year 2012 in review: biology

Radiographic scoring methods in hand osteoarthritis – a systematic literature search and descriptive review A.W. Visser, P. Bøyesen, I.K. Haugen, J.W.

Location-specific hip joint space width for progression of hip osteoarthritis – Data from the Osteoarthritis Initiative C. Ratzlaff, C. Van Wyngaarden,

R. B. Souza, C. Stehling, B. T. Wyman, M. -P. Hellio Le Graverand, X

L.A. Deveza, L. Melo, T.P. Yamato, K. Mills, V. Ravi, D.J. Hunter

Systematic review of the impact of osteoarthritis on health outcomes for comorbid disease in older people L. Parkinson, D.L. Waters, L. Franck Osteoarthritis.

Osteoarthritis and Cartilage

Osteoarthritis year in review 2016: mechanics

M. Doherty, P. Dieppe Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Presentation transcript:

TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg Osteoarthritis and Cartilage Volume 17, Issue 12, Pages 1539-1545 (December 2009) DOI: 10.1016/j.joca.2009.06.008 Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Schematic overview of factors that affect Smad signaling routes and that potentially shift the Smad2/3 and Smad1/5/8 signaling balance and chondrocyte differentiation. Osteoarthritis and Cartilage 2009 17, 1539-1545DOI: (10.1016/j.joca.2009.06.008) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions