Michael W.M. Kühn, Scott A. Armstrong  Cancer Cell 

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Designed to Kill: Novel Menin-MLL Inhibitors Target MLL-Rearranged Leukemia  Michael W.M. Kühn, Scott A. Armstrong  Cancer Cell  Volume 27, Issue 4, Pages 431-433 (April 2015) DOI: 10.1016/j.ccell.2015.03.012 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Inhibiting the Menin-MLL Interaction Causes Hox Gene Downregulation and Differentiation of MLL-Rearranged Leukemia (A) The menin-MLL interaction is required for Hox gene expression that is critical for MLL-rearranged leukemia. (B) Small-molecule MI-463 and MI-503 block the MLL binding site on menin, resulting in downregulation of Hox genes and differentiation of leukemic blasts. Cancer Cell 2015 27, 431-433DOI: (10.1016/j.ccell.2015.03.012) Copyright © 2015 Elsevier Inc. Terms and Conditions