miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof Thomas B. Huffaker, Ryan M. O’Connell  Immunity  Volume 43, Issue 1, Pages 3-4 (July 2015) DOI: 10.1016/j.immuni.2015.06.020 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 A Subset of miR-155 Functions in the Immune System Require Direct Repression of SOCS1 Repression of SOCS1 by miR-155 is necessary for NK cell expansion in response to MCMV, for CD8+ T cell expansion during chronic LCMV infection, and for Treg cell competitive fitness. However, miR-155 targets other than SOCS1 are necessary for additional miR-155 functions, including promotion of cytokine production by DCs, CD8+ T cell responses to acute viral infection, and Th17 cell differentiation. Immunity 2015 43, 3-4DOI: (10.1016/j.immuni.2015.06.020) Copyright © 2015 Elsevier Inc. Terms and Conditions