Antoni Bayés-Genís JCHF 2015;3:

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Antoni Bayés-Genís JCHF 2015;3:637-640 Schematic of NEP Activity (A) Normal physiology. (B) NEP inhibition by endogenous BNP or exogenous LCZ696. Ang II = angiotensin II; ANP = A-type natriuretic peptide; AT = angiotensin; BK = bradykinin; BNP = B-type natriuretic peptide; cGMP = cyclic guanosine monophosphate; CNP = C-type natriuretic peptide; ET = endothelin; GTP = guanosine triphosphate; NEP = neprilysin; NPR = natriuretic peptide receptor; RAAS = renin-angiotensin-aldosterone system; SbP = substance P; sNEP = soluble neprilysin. Antoni Bayés-Genís JCHF 2015;3:637-640 American College of Cardiology Foundation

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