Contrast agent electrostatic attraction rather than repulsion to glycosaminoglycans affords a greater contrast uptake ratio and improved quantitative.

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Presentation transcript:

Contrast agent electrostatic attraction rather than repulsion to glycosaminoglycans affords a greater contrast uptake ratio and improved quantitative CT imaging in cartilage P.N. Bansal, R.C. Stewart, V. Entezari, B.D. Snyder, M.W. Grinstaff Osteoarthritis and Cartilage Volume 19, Issue 8, Pages 970-976 (August 2011) DOI: 10.1016/j.joca.2011.04.004 Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Chemical structure of the contrast agents used in this study. Osteoarthritis and Cartilage 2011 19, 970-976DOI: (10.1016/j.joca.2011.04.004) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Linear regression analysis of average CT attenuation vs GAG content for three different contrast agents (Ioxaglate=red circles, Gadopentetate=green triangles, CA4+=blue diamonds). CT attenuation values are displayed in HU. GAG content reported as (mg of GAG)/(mg of hydrated cartilage). Osteoarthritis and Cartilage 2011 19, 970-976DOI: (10.1016/j.joca.2011.04.004) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Three dimensional CECT images of the same sample exposed to the three contrast agents used in the study. Color bar indicates the CECT attenuation in HU. The distribution of the cationic contrast agent (CA4+) reflects the depth-wise inhomogeneous distribution of GAGs in articular cartilage. Ioxaglate or Gadopentetate fail to reflect this distribution at the concentration used. Osteoarthritis and Cartilage 2011 19, 970-976DOI: (10.1016/j.joca.2011.04.004) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions